Pentalenolactone F synthase explained

Pentalenolactone F synthase
Ec Number:	1.14.11.36

Pentalenolactone F synthase (PEND (gene), PNTD (gene), PTLD (gene)) is an enzyme with systematic name pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

pentalenolactone D + 2 2-oxoglutarate + 2 O₂

\rightleftharpoons pentalenolactone F + 2 succinate + 2 CO₂ + H₂O (overall reaction)

(1a) pentalenolactone D + 2-oxoglutarate + O₂

\rightleftharpoons pentalenolactone E + succinate + CO₂ + H₂O

(1b) pentalenolactone E + 2-oxoglutarate + O₂

\rightleftharpoons pentalenolactone F + succinate + CO₂

Pentalenolactone F synthase contains Fe(II), and ascorbate is needed for its action.

Notes and References

1. Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE . Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone . Biochemistry . 50 . 10 . 1739–54 . March 2011 . 21250661 . 3051010 . 10.1021/bi1019786 .