Pentalenolactone D synthase explained

Pentalenolactone D synthase
Ec Number:	1.14.13.170

Pentalenolactone D synthase (penE (gene), pntE (gene)) is an enzyme with systematic name 1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (pentalenolactone-D forming).^[1] This enzyme catalyses the following chemical reaction

1-deoxy-11-oxopentalenate + NADPH + H⁺ + O₂

\rightleftharpoons pentalenolactone D + NADP⁺ + H₂O

Pentalenolactone D synthase is a FAD-dependent oxygenase.

Notes and References

1. Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE . Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone . Biochemistry . 50 . 10 . 1739–54 . March 2011 . 21250661 . 3051010 . 10.1021/bi1019786 .