Pentagestrone acetate explained
Pentagestrone acetate (PGA), sold under the brand names Gestovis and Gestovister, is a progestin which was described in the literature in 1960 and was introduced by Vister in Italy in 1961.[1] [2] [3] It is the 3-cyclopentyl enol ether of 17α-hydroxyprogesterone acetate.[4] PGA, along with quingestrone (the 3-cyclopentyl enol ether of progesterone), is said to have very similar properties to those of dydrogesterone, a pure progestogen and close analogue of progesterone.[5]
Notes and References
- Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 943–.
- Book: Drugs Available Abroad. 1991. Gale Research. 978-0-8103-7177-4.
- Book: List PH, Hörhammer L . Pentagestrone . Chemikalien und Drogen Teil A: N-Q. https://books.google.com/books?id=4TWnBgAAQBAJ&pg=PA508. 12 March 2013. Springer-Verlag. 978-3-642-65035-2. 508–.
- Book: Wermuth DG . Designing Prodrugs and Bioprecursors . Wermuth CG . The Practice of Medicinal Chemistry. https://books.google.com/books?id=Qmt1_DQkCpEC&pg=PA731. 2 May 2011. Academic Press. 978-0-08-056877-5. 731–. Camille Georges Wermuth.
- Gestovis . South African Medical Journal . 40 . 5 . January 1966 . 99 . 0256-9574 . Comopharm (Pty) Limited. on behalf of Vister Laboratories, announce the introduction of Gestovis, and supply the following information: Gestovis is a new highly effective oral progesterone derivative (cyclopentyl enol-ether of 17-alpha-acetoxy progesterone) for the treatment of threatened and habitual abortion and menstrual disturbances. Gestovis is efficacious orally at the same dose as parenterally administered progesterone. Dosage. 10 - 20 mg. daily or as necessary. Presentation. Available in capsules of 10 and 20 mg..
- Book: Pincus G . The Inhibition of Ovulation . The Control of Fertility. https://books.google.com/books?id=ehQlBQAAQBAJ&pg=PA221 . 3 September 2013. Elsevier. 978-1-4832-7088-3. 221–.
- Book: Current Medicine and Drugs. 1962. 32. Gestovis (3-cyclo-pentyl-enol ether of 17a acetoxyprogesterone) is a potent non-oestrogenic preparation but does not give very good cycle control. In doses of 20 mg daily from the fifth to the twenty-fifth day of the cycle it will inhibit ovulation..
- Edgren RA, Sturtevant FM . Potencies of oral contraceptives . American Journal of Obstetrics and Gynecology . 125 . 8 . 1029–1038 . August 1976 . 952300 . 10.1016/0002-9378(76)90804-8 .
- Book: Revue générale des sciences pures et appliquées et bulletin de l'Association française pour l'avancement des sciences. 1964. Société d'édition d'enseignement supérieur. ... Ercoli (1960) developed cyclopentyl enol ethers of progesterone (Luteovis) and acetoxy progesterone (Gestovis), which have almost exactly the same properties as dydrogesterone.]}}
PGA is orally active, was provided in 10 and 20 mg capsules, and has been used to treat habitual abortion and menstrual disorders at a dosage of 10 to 20 mg/day.[5] It has been said to have equivalent potency to intramuscular progesterone. The combination of 20 mg/day PGA and 100 μg/day mestranol is an effective ovulation inhibitor in women.[6] [7] The effective dosage of PGA in the menstrual delay test has been studied.[8]
Chemistry
See also: List of progestogens, Progestogen ester and List of progestogen esters.
PGA, also known as 17α-acetoxyprogesterone 3-cyclopentyl enol ether, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone.
See also
References
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