Pentafluorophenol Explained

Pentafluorophenol is the organofluorine compound (specifically a fluoroalcohol) with the formula . This is the perfluorinated analogue of phenol. It is a white odorless solid that melts just above room temperature. With a pK_a of 5.5, it is one of the most acidic phenols.

Uses

Pentafluorophenol is used to prepare pentafluorophenyl esters, which are active esters useful in peptide synthesis.^[1]

Environmental hazards

Pentafluorophenol is considered hazardous because of oral, dermal and inhalation toxicity and because it causes severe skin burns and eye damage.^{[2] [3]}

Notes and References

1. Encyclopedia: Pentafluorophenol. Jones K, DeAmicis C. Encyclopedia of Reagents for Organic Synthesis. 2009. 1–9. 10.1002/047084289X. 10261/236866. free.
2. Web site: Pentafluorophenol SAFETY DATA SHEET . Thermo Fisher Scientific . 26 February 2021 . January 18, 2018.
3. Web site: Pentafluorophenol . PubChem . National Center for Biotechnology Information . 26 February 2021 . February 20, 2021.