| Pennes-le-Sec | |
| Commune Status: | Commune |
| Arrondissement: | Die |
| Canton: | Le Diois |
| Insee: | 26228 |
| Postal Code: | 26340 |
| Mayor: | Marielle Peyroche[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Diois |
| Coordinates: | 44.6389°N 5.3192°W |
| Elevation Min M: | 421 |
| Elevation Max M: | 1339 |
| Area Km2: | 9.31 |
Pennes-le-Sec (in French pronounced as /pɛn lə sɛk/; Occitan (post 1500);: La Pena) is a commune in the Drôme department in southeastern France.