Penamecillin Explained

Penamecillin, an acetoxymethyl ester of benzylpenicillin, is a prodrug processed to benzylpenicillin by esterases.^[1] It has no detectable teratogenic risk to the fetus.^[2]

Notes and References

1. Agersborg HP, Batchelor A, Cambridge GW, Rule AW . The pharmacology of penamecillin . British Journal of Pharmacology and Chemotherapy . 26 . 3 . 649–655 . March 1966 . 4959939 . 1510697 . 10.1111/j.1476-5381.1966.tb01844.x .
2. Czeizel AE, Rockenbauer M, Sørensen HT, Olsen J . The Safety of Penicillin V: Oral Penamecillin Use During Pregnancy The Importance and Limitation of Recall Bias . Congenital Anomalies . 39 . 4 . 1999 . 0914-3505 . 10.1111/j.1741-4520.1999.tb00566.x . 267–279.