Pemafibrate Explained

Iupac Name:(2R)-2-[3-({1,3-Benzoxazol-2-yl[3-(4-methoxyphenoxy)propyl]amino}methyl)phenoxy]butanoic acid
Tradename:Parmodia
Routes Of Administration:Oral
Atc Prefix:C10
Atc Suffix:AB12
Legal Status:Rx-only
Cas Number:848259-27-8
Chemspiderid:9700824
Unii:17VGG92R23
Kegg:D10711
Chebi:228365
Chembl:247951
Synonyms:K-13675
C:28
H:30
N:2
O:6
Smiles:CC[C@H](C(=O)O)Oc1cccc(c1)CN(CCCOc2ccc(cc2)OC)c3nc4ccccc4o3
Stdinchi:1S/C28H30N2O6/c1-3-25(27(31)32)35-23-9-6-8-20(18-23)19-30(28-29-24-10-4-5-11-26(24)36-28)16-7-17-34-22-14-12-21(33-2)13-15-22/h4-6,8-15,18,25H,3,7,16-17,19H2,1-2H3,(H,31,32)/t25-/m1/s1
Stdinchikey:ZHKNLJLMDFQVHJ-RUZDIDTESA-N

Pemafibrate, sold under the brand namd Parmodia, is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. It is developed and marketed by Kowa Pharmaceuticals.[1]

In July 2017, Pharmaceuticals and Medical Devices Agency approved it in Japan.[2]

Notes and References

  1. Yamashita S, Masuda D, Matsuzawa Y . Pemafibrate, a New Selective PPARα Modulator: Drug Concept and Its Clinical Applications for Dyslipidemia and Metabolic Diseases . Current Atherosclerosis Reports . 22 . 1 . 5 . January 2020 . 31974794 . 6978439 . 10.1007/s11883-020-0823-5 .
  2. http://en.pharmacodia.com/web/drug/1_1539.html Pemafibrate