| Pellegrini Department | |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | 180px |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Santiago del Estero |
| Seat Type: | Capital |
| Seat: | Nueva Esperanza |
| Unit Pref: | Metric |
| Timezone1: | ART |
Pellegrini Department is a department of Argentina in Santiago del Estero Province. The capital city of the department is in Nueva Esperanza.
Pellegrini is located in the far northwest corner of Santiago del Estero. It borders Salta Province and Tucumán Province.