Pegozafermin Explained

Drug Name:	Pegozafermin
Synonyms:	BIO89-100; TEV-47948
Legal Status:	Investigational
Cas Number:	2489589-60-6
Unii:	UO870O6MFS

Pegozafermin (BIO89-100) is a long-acting, glycopegylated FGF21 analog developed for the treatment of nonalcoholic steatohepatitis and hypertriglyceridemia.^{[1] [2] [3] [4]}

Notes and References

1. Loomba . Rohit . Sanyal . Arun J. . Kowdley . Kris V. . Bhatt . Deepak L. . Alkhouri . Naim . Frias . Juan P. . Bedossa . Pierre . Harrison . Stephen A. . Lazas . Donald . Barish . Robert . Gottwald . Mildred D. . Feng . Shibao . Agollah . Germaine D. . Hartsfield . Cynthia L. . Mansbach . Hank . Margalit . Maya . Abdelmalek . Manal F. . Randomized, Controlled Trial of the FGF21 Analogue Pegozafermin in NASH . New England Journal of Medicine . 14 September 2023 . 389 . 11 . 998–1008 . 10.1056/NEJMoa2304286. 10718287 .
2. Bhatt . Deepak L. . Bays . Harold E. . Miller . Michael . Cain . James E. . Wasilewska . Katarzyna . Andrawis . Nabil S. . Parli . Teresa . Feng . Shibao . Sterling . Lulu . Tseng . Leo . Hartsfield . Cynthia L. . Agollah . Germaine D. . Mansbach . Hank . Kastelein . John J. P. . The FGF21 analog pegozafermin in severe hypertriglyceridemia: a randomized phase 2 trial . Nature Medicine . July 2023 . 29 . 7 . 1782–1792 . 10.1038/s41591-023-02427-z . en . 1546-170X. free . 10353930 .
3. Loomba . Rohit . Lawitz . Eric J . Frias . Juan Pablo . Ortiz-Lasanta . Grisell . Johansson . Lars . Franey . Bridgette Boggess . Morrow . Linda . Rosenstock . Moti . Hartsfield . Cynthia L . Chen . Chao-Yin . Tseng . Leo . Charlton . R Will . Mansbach . Hank . Margalit . Maya . Safety, pharmacokinetics, and pharmacodynamics of pegozafermin in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 1b/2a multiple-ascending-dose study . The Lancet Gastroenterology & Hepatology . February 2023 . 8 . 2 . 120–132 . 10.1016/S2468-1253(22)00347-8.
4. Alkhouri . Naim . Lazas . Donald . Loomba . Rohit . Frias . Juan P. . Feng . Shibao . Tseng . Leo . Balic . Kemal . Agollah . Germaine D. . Kwan . Tinna . Iyer . Janani S. . Morrow . Linda . Mansbach . Hank . Margalit . Maya . Harrison . Stephen A. . Clinical trial: Effects of pegozafermin on the liver and on metabolic comorbidities in subjects with biopsy‐confirmed nonalcoholic steatohepatitis . Alimentary Pharmacology & Therapeutics . November 2023 . 58 . 10 . 1005–1015 . 10.1111/apt.17709. free .