| Honorific-Prefix: | General |
| Pedro de Roxas y Acevedo | |
| Office1: | Interim Governor of the Río de la Plata and Paraguay |
| Term Start1: | 1641 |
| Term End1: | 1641 |
| Predecessor1: | Andrés de Sandoval |
| Successor1: | Jerónimo Luis de Cabrera |
| Order3: | Lieutenant Governor of Buenos Aires |
| Term Start3: | 1641 |
| Term End3: | 1642 |
| Predecessor3: | Juan Bernardo de la Cueva |
| Successor3: | Luis de Aresti |
| Order4: | Vice-Mayor of Buenos Aires |
| Term Start4: | 1626 |
| Term End4: | 1627 |
| Predecessor4: | Antonio Gutiérrez Barragán |
| Successor4: | Francisco García Romero |
| Order5: | Escribano of the Cabildo of Buenos Aires |
| Term Start5: | 1620 |
| Term End5: | 1626 |
| Predecessor5: | Jerónimo de Medrano |
| Successor5: | Alonso Agreda de Vergara |
| Birth Date: | c. 1594 |
| Birth Place: | Canary Islands, Spain |
| Death Date: | c. 1670 |
| Death Place: | Buenos Aires, Argentina |
| Spouse: | María de Vega |
| Signature: | Pedro de Roxas y Acevedo, firma.jpg |
| Serviceyears: | c. 1614-1660s |
| Rank: | General |
| Unit: | Fuerte de Buenos Aires |
Pedro de Roxas Acevedo (c. 1594-1670s) was a Spanish military officer, and politician, who served in Buenos Aires and Asunción holding honorary positions, including the post of Governor of the Río de la Plata and Paraguay, on an interim term between January 8, 1641, to July 17, 1641.
He was born in Garachico (Tenerife, Spain), son of Amador de Acevedo and Catalina de Roxas, natives of Madrid. He had arrived at the Río de la Plata from Cádiz in 1612. After establishing himself in the city, he held the post of notary public of the Cabildo of Buenos Aires in 1620.
He was elected alcalde in second vote in 1626, and also served as regidor of the Ayuntamiento. In 1641, Roxas was appointed as lieutenant governor of Buenos Aires, being designated that same year to occupy of interim form the governorship of the Río de la Plata.
Pedro de Roxas Acevedo was married to doña María de Vega, daughter of Diego de Vega and Blanca de Vasconcelos. His sons, Thomas de Roxas and Amador de Roxas, were two important political officials of the 17th century . He and his family received very large land grants in Buenos Aires, being considered one of the richest men of his time.