Paula Booth Explained

Paula Booth
Birth Name:Paula Jane Booth
Nationality:English
Fields:Chemistry and Biochemistry
Workplaces:King's College, London
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Known For:Study of Lipids and Membranes
Awards:Philip Leverhulme Prize

Paula Jane Booth is an English chemist who holds the Daniell Chair of Chemistry at King's College London and is Head of Department.[1] Booth was awarded a Philip Leverhulme Prize in 2003, a Royal Society Wolfson Research Merit Award in 2008 and an ERC Advanced grant in 2012 for her novel work on investigating the mechanisms of biological self-assembly.[2] [3] [4]

Education and academic career

Booth studied for a BA Hons in Chemistry at St John’s College, Oxford. Booth undertook a PhD to study the thermodynamic properties of electron transfer in Photosystem 2 reaction centres, at Imperial College, London, under the supervisor of George Porter and James Barber. Following a short fellowship at the Centre D-Etudes de Saclay outside Paris, Booth set up her own research group at the University of Oxford, whilst holding a Research Fellowship at Corpus Christi College. After this, Booth moved to Imperial College and then the University of Bristol where she was appointed professor in 2005. In 2014 Booth was appointed Daniell Chair and Head of Department at King's College London. She is also on the academic staff at The London Centre for Nanotechnology.[5]

Research interests

At the University of Bristol, Booth investigated the minimal lipid composition which allows insertion of membrane proteins.[6] Booth's current research studies how membrane lipids impact on membrane protein folding and activity.[7] Booth also investigates the design of artificial membrane proteins and lipids to develop synthetic biology systems to apply to useful applications.[8] [9] Techniques from many disciplines are put to use by Booth to measure and alter properties of membrane lipids and proteins.[10] [11]

Professional associations and awards

Notes and References

  1. Web site: King's College London - Head of Department. www.kcl.ac.uk. 2019-02-09.
  2. Web site: List of Philip Leverhulme prize winners.
  3. Web site: Paula Booth Royal Society. royalsociety.org. en-gb. 2019-02-09.
  4. Web site: List of ERC Advanced grants 2011.
  5. Web site: The London Centre for Nanotechnology.
  6. Meijberg. Wim. Booth. Paula J.. 2002-06-07. The Activation Energy for Insertion of Transmembrane α-Helices is Dependent on Membrane Composition. Journal of Molecular Biology. 319. 3. 839–853. 10.1016/S0022-2836(02)00342-X. 12054874. 0022-2836.
  7. Booth. Paula J.. Findlay. Heather E.. Charalambous. Kalypso. Harris. Nicola J.. 2018-10-19. Lipids modulate the insertion and folding of the nascent chains of alpha helical membrane proteins. Biochemical Society Transactions. en. 46. 5. 1355–1366. 10.1042/BST20170424. 0300-5127. 30190329. 52168815 .
  8. Fletcher. Jordan M.. Boyle. Aimee L.. Bruning. Marc. Bartlett. Gail J.. Vincent. Thomas L.. Zaccai. Nathan R.. Armstrong. Craig T.. Bromley. Elizabeth H. C.. Booth. Paula J.. 2012-06-15. A Basis Set of de Novo Coiled-Coil Peptide Oligomers for Rational Protein Design and Synthetic Biology. ACS Synthetic Biology. 1. 6. 240–250. 10.1021/sb300028q. 23651206. 1887/45977. free.
  9. Simms. John. Booth. Paula J. 2013-12-01. Membrane proteins by accident or design. Current Opinion in Chemical Biology. Synthetic biology • Synthetic biomolecules. 17. 6. 976–981. 10.1016/j.cbpa.2013.10.005. 24466578. 1367-5931.
  10. Martens. Chloe. Shekhar. Mrinal. Borysik. Antoni J.. Lau. Andy M.. Reading. Eamonn. Tajkhorshid. Emad. Booth. Paula J.. Politis. Argyris. 2018-10-08. Direct protein-lipid interactions shape the conformational landscape of secondary transporters. Nature Communications. 9. 1. 4151. 10.1038/s41467-018-06704-1. 2041-1723. 6175955. 30297844.
  11. Hellwig. Nils. Peetz. Oliver. Ahdash. Zainab. Tascón. Igor. Booth. Paula J.. Mikusevic. Vedrana. Diskowski. Marina. Politis. Argyris. Hellmich. Yvonne. 2018-12-18. Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs. Chemical Communications. 54. 97. 13702–13705. 10.1039/c8cc06284f. 1359-7345. 6289172. 30452022.
  12. Web site: 2003: Innovative, high-risk research News University of Bristol. Bristol. University of. www.bristol.ac.uk. en-GB. 2019-02-09.
  13. Web site: 2008: RS Wolfson Awards News University of Bristol. Bristol. University of. www.bristol.ac.uk. en-GB. 2019-02-09.
  14. Web site: Prof. Paula Booth - AcademiaNet. www.academia-net.org. 2019-02-09.

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