| Paul Desjardins | |
| Birth Date: | 27 September 1943 |
| Birth Place: | Ottawa, Ontario |
| Status: | Retired |
| Import: | no |
| Position1: | Centre |
| Height Ft: | 6 |
| Height In: | 3 |
| Weight Lb: | 248 |
| Cis: | Ottawa |
| Playing Years1: | – |
| Playing Team1: | Winnipeg Blue Bombers |
| Playing Years2: | – |
| Playing Team2: | Toronto Argonauts |
| Cfleastallstar: | ,, |
Paul Desjardins (born September 27, 1943 in Ottawa, Ontario) is a former all-star professional Canadian football offensive lineman who played nine seasons in the Canadian Football League.