Paul Sigler Explained

Paul B. Sigler
Birth Date:	19 February 1934^[1]
Birth Place:	Richmond, Virginia, US
Death Place:	New Haven, Connecticut, US
Nationality:	American
Occupation:	Professor
Children:	5 children
Module:	Embed: yes Known For: Phospholipase A2 trp repressor Doctoral Advisors: David M. Blow^[2] Workplaces: Yale University University of Chicago MRC-LMB NIH Field: Biophysics Biochemistry Alma Mater: Princeton University Columbia University (MD) Cambridge University (PhD) Awards: National Academy of Sciences HHMI Investigator^[3] Guggenheim Fellow Helen Hay Whitney Fellow^[4]
Spouse:	Althea Jo Martin Sigler

Paul B. Sigler (19 February 1934 – ^{[5] [1]}) was the Henry Ford II Professor of Molecular Biophysics and Biochemistry at Yale University.^{[6] [7]} Major awards included membership in the National Academy of Sciences, HHMI Investigator status, and Guggenheim and Helen Hay Whitney Fellowships.^[4] He is noted for pioneering studies of Phospholipase A2 and trp repressor amongst many others.^[1]

Biography

Prior to coming to Yale, he was a professor at the University of Chicago. He received his MD from Columbia University in 1959 and his undergraduate degree from Princeton University in 1955. After briefly practicing medicine and working as a researcher for the NIH,^[4] he would go on to earn a second doctorate, a PhD, from Cambridge University at the Laboratory of Molecular Biology^[8] working under David M. Blow^[2] before moving to the University of Chicago.^[8]

Memorials

A memorial plaque is located in front of the Bass Center for Structural Biology on Science Hill on the campus of Yale University. Yale has a Paul Sigler Memorial Prize for undergraduate research in Molecular Biophysics & Biochemistry. Yale also has sponsored Paul Sigler memorial symposia in the past.^[9] The Agouron Institute sponsored 12 Paul Sigler fellowships between 2000 and 2006.^[10]

Death

Paul Sigler died on January 11, 2000, at New Haven, Connecticut, US, about a month before his 66th birthday.

Selected publications

• 10.1038/379311a0. 8552184. The 2.0 Å crystal structure of a heterotrimeric G protein. Nature. 379. 6563. 311–9. 1996. Lambright. David G.. Sondek. John. Bohm. Andrew. Skiba. Nikolai P.. Hamm. Heidi E.. Sigler. Paul B.. 1996Natur.379..311L. 4350943.
• 10.1038/352497a0. 1865905. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature. 352. 6335. 497–505. 1991. Luisi. B. F.. Xu. W. X.. Otwinowski. Z.. Freedman. L. P.. Yamamoto. K. R.. Sigler. P. B.. 1991Natur.352..497L. 1919276.
• 10.1038/371578a0. 7935790. The crystal structure of the bacterial chaperonln GroEL at 2.8 Å. Nature. 371. 6498. 578–86. 1994. Braig. Kerstin. Otwinowski. Zbyszek. Hegde. Rashmi. Boisvert. David C.. Joachimiak. Andrzej. Horwich. Arthur L.. Sigler. Paul B.. 1994Natur.371..578B. 4341993.
• 10.1038/365512a0. 8413604. Crystal structure of a yeast TBP/TATA-box complex. Nature. 365. 6446. 512–20. 1993. Kim. Youngchang. Geiger. James. H.. Hahn. Steven. Sigler. Paul B.. 1993Natur.365..512K. 4336203.
• 10.1126/science.2683088. 2683088. Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science. 246. 4932. 911–6. 1989. Vinson. C.. Sigler. P.. McKnight. S.. 1989Sci...246..911V.
• 3419502. 1988. Otwinowski. Z. Crystal structure of trp repressor/operator complex at atomic resolution. Nature. 335. 6188. 321–9. Schevitz. R. W.. Zhang. R. G.. Lawson. C. L.. Joachimiak. A. Marmorstein. R. Q.. Luisi. B. F.. Sigler. P. B.. 10.1038/335321a0. 1988Natur.335..321O. 9358980.

See also

• List of Guggenheim Fellowships awarded in 1974
• List of University of Chicago people

Further reading

• News: New York Times Obit. The New York Times . 15 January 2000 . Saxon . Wolfgang .
• Web site: Yale obit.
• Web site: (IUCr) Paul B. Sigler (1934-2000).
• Web site: Paul Sigler (1934-2000) MRC Laboratory of Molecular Biology.
• Obituary: Paul Sigler (1934–2000). 848. Brian W. Matthews. Nature. 403. 6772. 10.1038/35002722. 2000. 10706270. 2000Natur.403..848M. 205004640. free.
• 10.1038/74024. Nature Structural Biology. 7. 4. 271–272. Paul Sigler: A structural biologist with passion. 2000. Henderson. Richard. 34789342. free.
• 10.1016/S0968-0004(00)01587-5. Trends in Biochemical Sciences. 25. 5. 221–2. Paul Sigler (1934–2000). 2000. Jeruzalmi. David. Kuriyan. John. Doudna. Jennifer. 10782089.
• Protein Science. Paul Sigler (1934–2000). 9. 4. 827–828. 2144625. 2000. Horwich. A. Joachimiak. A.
• Cell. 101. 1. 23–4. 10.1016/S0092-8674(02)71111-2. 10778852. Paul Sigler (1934–2000). 2000. Perutz. Max. free.
• 10.1016/S0969-2126(00)00113-1. 10745016. Obituary: Paul Sigler. Structure. 8. 3. R67–8. 2000. Davies. David R. free.

External links

• • Paul B. Sigler on AcademicTree

Notes and References

1. Web site: (IUCr) Paul B. Sigler (1934-2000).
2. Web site: Blow on AcademicTree.org.
3. Web site: Paul B. Sigler, MD, PhD - HHMI.org. HHMI.org.
4. Web site: Paul Sigler (1934-2000) MRC Laboratory of Molecular Biology.
5. http://www.nasonline.org/member-directory/deceased-members/43385.html National Academy of Sciences
6. Web site: Yale University Press Release. 23 October 1998 .
7. Web site: Official Site.
8. News: New York Times Obit. The New York Times . 15 January 2000 . Saxon . Wolfgang .
9. Web site: Paul Sigler Symposium.
10. Web site: Helen Hay Whitney Foundation - Announcement.