Patrik Brundin Explained

Patrik Brundin
Birth Name:Patrik Brundin
Birth Date:26 December 1961
Birth Place:Malmö, Sweden
Nationality:Swedish
American
Occupation:Neuroscientist
Known For:Research on Parkinson's disease (PD) and Huntington's disease

Patrik Brundin (born December 26, 1961, in Malmö, Sweden) is a neuroscientist known for his research on Parkinson's disease (PD) and Huntington's disease.[1] [2] [3] He is currently a Distinguished Scientist and serving as Therapeutic Area Leader for Movement Disorders at F. Hoffmann-La Roche, Pharmaceutical Research and Early Development (pRED).[4] [5]

Brundin was educated at Lund University from 1980 to 1992, where he became a full professor in 2000. In 2012, he was appointed the Jay Van Andel Endowed Chair in Parkinson's Research at Van Andel Institute, Grand Rapids, Michigan.[6] Before moving to F. Hoffmann-La Roche in 2022, Brundin held multiple roles at the institute such as the Deputy Chief Scientific Officer, the Director of the Center for Neurodegenerative Science and the Parkinson's Disease Center.[7] [8] [9]

Early life and education

Already at age 12, Brundin became interested in studying and finding a cure for PD, a passion influenced by his father's, Bertil Brundin, diagnosis in 1974.[10] [11] [12] While born in Sweden, Brundin spent the majority of his early childhood in the UK, before the family's return to Sweden in 1975.[13] [14]

In 1978, Brundin was granted a scholarship to United World College (UWC) of the Atlantic, an international boarding school in Wales, UK.[15] [11] At age 17, he started his research with an Extended Essay on PD as part of the International Baccalaureate (IB) program.[10] Upon completion of his IB diploma in 1980, he entered medical school at Lund University in Sweden and embarked on an M.D.-Ph.D. program. He completed his Bachelor of Science in Medicine in 1983, a Ph.D. in 1988 under the supervision of Swedish neuroscientist Anders Björklund, and an M.D. in 1992.[16]

Career

In 1994, Brundin started his own independent research group at Lund University, Sweden, and he was promoted to full professor of neuroscience at the Faculty of Medicine in 2000.[17] [18] [19] His team moved to the Wallenberg Neuroscience Center at Lund University in 1996.[20]

In 2011, Brundin was awarded a European Research Council grant to study disease mechanisms in PD. In 2012, he moved to the USA and joined the Van Andel Institute, serving both as the Director of the Center for Neurodegenerative Science and the Head of the Laboratory for Translational Parkinson's Disease Research.[13] [21] He later held positions as the Deputy Chief Scientific Officer and the Director of the Parkinson's Disease Center at the same institute until 2022.[9] During this period, he also chaired the scientific committee of the International Linked Clinical Trials initiative.[22] In 2022, he moved to F. Hoffmann-La Roche where he became a Distinguished Scientist where he has the role of Therapeutic Area Leader for Movement Disorders.[4]

Brundin is highly cited, with more than four hundred publications on PD and Huntington's Diseases.[22] He contributed to cell transplantation for PD, took part in initial successful clinical trials, and oversaw subsequent methodological refinements. His work expanded to include the molecular mechanisms of these diseases, co-authoring with Nobel laureate Aaron Ciechanover, a 2002 review on the potential role of impaired protein degradation in neurodegenerative disorders. He and collaborators identified the prion-like propagation of alpha-synuclein aggregates between neurons and developed corresponding animal models. This work contributed to the recognition of alpha-synuclein as a potential therapeutic target in PD.[23] [24] [25] In 2021, Brundin was listed on the Clarivate Highly Cited Researchers List.[22] Since 2022, at F. Hoffmann-La Roche, he has maintained his research focus on alpha-synuclein, participating in clinical trials studying this protein.

Brundin has also had several other scientific leadership roles. In 2011 he was a founding co-editor-in-chief of the Journal of Parkinson's Disease and he served in that role for over a decade.[4] Starting in 2012, he served for a decade as the inaugural chair of the International Linked Clinical Trials committee, which was instrumental in conducting the largest drug repurposing program in Parkinson's Disease (PD).[26] He has been a member of the World Parkinson Coalition Board of Directors and the MJ Fox Foundation Executive Scientific Advisory Board.[27] [9] He has also chaired a study section at the National Institutes for Neurological Disease and Stroke (NINDS).[28] He is a scientific co-founder of the biotech companies Acousort AB and RYNE Biotechnology, the latter focused on induced pluripotent stem cell (iPSC)-based transplantation therapy for PD.[29]

Awards and recognition

Further reading

Notes and References

  1. Web site: Möt en av världens främsta Parkinsonforskare.. March 19, 2011. Sydsvenskan. 2023-08-07. 2023-08-07. https://web.archive.org/web/20230807174136/https://www.sydsvenskan.se/2011-03-19/forskare-med-fokus-pa-parkinson. live.
  2. News: Hopp om tidig medicin mot Parkinson. Dagens Nyheter. January 19, 2011. www.dn.se. August 7, 2023. August 7, 2023. https://web.archive.org/web/20230807191148/https://www.dn.se/nyheter/vetenskap/hopp-om-tidig-medicin-mot-parkinson/. live.
  3. Web site: Sorenson . Aaron . Productivity and Impact of the Top 100 Cited Parkinson's Disease Investigators since 1985 . Journal of Parkinson's Disease . 15 October 2018 . 2011 . 25 October 2017 . https://web.archive.org/web/20171025230648/https://content.iospress.com/download/journal-of-parkinsons-disease/jpd10021?id=journal-of-parkinsons-disease%2Fjpd10021 . live .
  4. Web site: Patrik Brundin Steps Down as JPD Co-Editor-in-Chief | Journal of Parkinson's Disease. 2023-08-07. 2023-08-07. https://web.archive.org/web/20230807172633/https://www.journalofparkinsonsdisease.com/patrik-brundin-steps-down-as-jpd-co-editor-in-chief. live.
  5. Web site: Q&A with Dr. Patrik Brundin . 2023-08-29 . 2023-08-29 . https://web.archive.org/web/20230829094241/https://www.jones-dilworth.com/superposition/q-a-with-dr-patrik-brundin/ . live .
  6. Web site: Patrik Brundin, MD, PHD . Michael J. Fox Foundation for Parkinson's Research . 15 October 2018 . 15 October 2018 . https://web.archive.org/web/20181015153322/https://www.michaeljfox.org/foundation/researchers.php?id=471 . live .
  7. Web site: Dutch program could make Grand Rapids a destination for Parkinson's care. May 29, 2015. mlive. August 7, 2023. August 7, 2023. https://web.archive.org/web/20230807174134/https://www.mlive.com/business/west-michigan/2015/05/dutch_program_could_make_grand.html. live.
  8. Web site: West Michigan scientists find hope in slowing Parkinson's disease. December 22, 2016. Fox 17 West Michigan News (WXMI). August 7, 2023. August 7, 2023. https://web.archive.org/web/20230807172635/https://www.fox17online.com/2016/12/22/west-michigan-scientists-find-possible-hope-in-slowing-parkinsons-disease. live.
  9. Web site: Patrik Brundin, MD, PhD | Parkinson's Disease. www.michaeljfox.org. 2023-08-07. 2023-08-07. https://web.archive.org/web/20230807172636/https://www.michaeljfox.org/researcher/patrik-brundin-md-phd. live.
  10. Web site: UWC - The never-ending Extended Essay: UWC Alumnus on his way to curing Parkinson's Disease. 2021-11-20. 2021-11-20. https://web.archive.org/web/20211120051609/https://www.uwc.org/news/?pid=37&nid=3&storyid=4656. live.
  11. Web site: 'Close to a breakthrough'. Sarah. Marilyn. May 4, 2021. August 7, 2023. August 7, 2023. https://web.archive.org/web/20230807172908/https://www.grmag.com/people-places/issues/close-to-a-breakthrough/. live.
  12. Web site: Archived copy . 2023-08-29 . 2023-08-29 . https://web.archive.org/web/20230829094236/https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(19)30112-7/fulltext . live .
  13. Web site: Profile: Patrik Brundin | Journal of Parkinson's Disease. 2021-11-20. 2021-11-20. https://web.archive.org/web/20211120051620/https://www.journalofparkinsonsdisease.com/blog/neuroscientists_corner/profile-patrik-brundin. live.
  14. Web site: Archived copy . 2023-08-29 . 2023-08-29 . https://web.archive.org/web/20230829094236/https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(19)30112-7/fulltext . live .
  15. Web site: Profile: Patrik Brundin. 2021-11-20. www.journalofparkinsonsdisease.com. 2021-11-20. https://web.archive.org/web/20211120051620/https://www.journalofparkinsonsdisease.com/blog/neuroscientists_corner/profile-patrik-brundin. live.
  16. Web site: The never-ending Extended Essay: UWC Alumnus on his way to curing Parkinson's Disease. 2021-11-20. 2021-11-20. https://web.archive.org/web/20211120051609/https://www.uwc.org/news/?pid=37&nid=3&storyid=4656. live.
  17. Web site: For Van Andel Institute's new lead scientist in Parkinson's research, fight against disease is personal. Sue. Thoms. October 27, 2011. mlive. August 7, 2023. August 7, 2023. https://web.archive.org/web/20230807174135/https://www.mlive.com/business/west-michigan/2011/10/grand_rapidsvan_andel_institut.html. live.
  18. Web site: Professor Patrik Brundin co-founder of new biotechnology company . Lund University, Faculty of Medicine . Lund University . 15 October 2018 . 15 October 2018 . https://web.archive.org/web/20181015153351/https://www.med.lu.se/multipark/news_archive/20090525_new_biotechnology_company . live .
  19. Web site: Hjärnans mysterier lockade. November 6, 2005. Kristianstadsbladet. August 7, 2023. August 7, 2023. https://web.archive.org/web/20230807174026/https://www.kristianstadsbladet.se/kristianstad/hjarnans-mysterier-lockade/. live.
  20. Web site: Parkinson's brain cell transplants last for years. April 6, 2008. NBC News. August 7, 2023. August 7, 2023. https://web.archive.org/web/20230807174026/https://www.nbcnews.com/id/wbna23982576. live.
  21. Web site: Kritisk toppforskare lämnar Lund för USA. November 8, 2011. Sydsvenskan. 2023-08-07. 2023-08-07. https://web.archive.org/web/20230807174027/https://www.sydsvenskan.se/2011-11-08/kritisk-toppforskare-lamnar-lund-for-usa. live.
  22. Web site: VAI scientists named to Highly Cited Researchers list. Rachel. Watson. November 17, 2021. August 7, 2023. August 7, 2023. https://web.archive.org/web/20230807173450/https://www.crainsgrandrapids.com/news/health-care/vai-scientists-named-to-highly-cited-researchers-list/. live.
  23. Web site: Closing in on a Parkinson's drug: Van Andel scientist hopes study will lead to way to halt disease. Sue. Thoms. June 27, 2012. mlive. August 11, 2023. August 11, 2023. https://web.archive.org/web/20230811215340/https://www.mlive.com/business/west-michigan/2012/06/closing_in_on_a_parkinsons_dru.html. live.
  24. Web site: Hopp om tidig medicin mot parkinson. Hälsoliv. 2023-08-11. 2023-08-11. https://web.archive.org/web/20230811215343/https://www.expressen.se/halsoliv/hopp-om-tidig-medicin-mot-parkinson/. live.
  25. News: Ny ledtråd om Parkinsons sjukdom. Mikaela. Åkerman. Svenska Dagbladet. August 14, 2011. www.svd.se. August 11, 2023. August 11, 2023. https://web.archive.org/web/20230811220843/https://www.svd.se/a/7b640533-3c75-3713-9aea-01945bb60ea5/ny-ledtrad-om-parkinsons-sjukdom. live.
  26. Web site: The International Linked Clinical Trials (iLCT) programme. Cure Parkinson's. 2023-08-11. 2023-08-11. https://web.archive.org/web/20230811220717/https://cureparkinsons.org.uk/research/ilct/. live.
  27. Web site: WPCVirtual - World Parkinson Coalition. www.worldpdcoalition.org. 2023-08-11. 2023-08-11. https://web.archive.org/web/20230811220405/https://www.worldpdcoalition.org/page/WPCVirtual. live.
  28. Web site: eRA Browser Warning. public.era.nih.gov. 2024-04-28. 2023-08-11. https://web.archive.org/web/20230811220716/https://public.era.nih.gov/pubroster/preRosIndex.era?AGENDA=439448&CID=100925. live.
  29. Web site: OPDC Scientific Advisory Board . Oxford Parkinson's Disease Centre . 15 October 2018 . 15 October 2018 . https://web.archive.org/web/20181015153039/https://www.opdc.ox.ac.uk/sab . live .
  30. Web site: Academy of Europe: Brundin Patrik. www.ae-info.org. 2023-08-07. 2023-03-20. https://web.archive.org/web/20230320145535/https://www.ae-info.org/ae/Member/Brundin_Patrik. live.
  31. Web site: 2001 CAG Triplet Repeat Disorders Conference GRC. www.grc.org. 2023-08-11. 2023-08-11. https://web.archive.org/web/20230811220102/https://www.grc.org/cag-triplet-repeat-disorders-conference/2001/. live.
  32. Web site: Archived copy . 2023-08-11 . 2023-08-11 . https://web.archive.org/web/20230811215931/https://www.umu.se/globalassets/centralwebb/om-umea-universitet/nyheter-och-evenemang/akademiska-hogtider/arshogtiden/2011_hogtidsskrift_arshogtiden.pdf . live .
  33. Web site: Who We Are. Blythe. Lloyd. Aligning Science Across Parkinson's. 2023-08-11. 2023-08-11. https://web.archive.org/web/20230811215931/https://parkinsonsroadmap.org/who-we-are/. live.
  34. Web site: WCN 2019 Plenary Sessions. wfneurology.org. 2023-08-11. 2023-08-11. https://web.archive.org/web/20230811215926/https://wfneurology.org/wcn-2019-dubai/wcn-2019-plenary-sessions. live.
  35. Web site: 2022 Tom Isaacs Award honours leading Parkinson's researchers and co-authors of Ending Parkinson's. Kirsten. Murray. September 29, 2022. Cure Parkinson's. August 7, 2023. August 7, 2023. https://web.archive.org/web/20230807173449/https://cureparkinsons.org.uk/2022/09/2022-tom-isaacs-award-honours-leading-parkinsons-researchers-and-co-authors-of-ending-parkinsons/. live.

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