| Church: | Church of Constantinople |
| Archbishop Of: | Ecumenical Patriarch of Constantinople |
| Term: | 1260 – 25 July 1261 |
| Predecessor: | Arsenios Autoreianos |
| Successor: | Arsenios Autoreianos |
| Birth Date: | ? |
| Death Date: | 25 July 1261 |
Nikephoros II or Nicephorus II (Greek: Νικηφόρος; died 25 July 1261) was a Byzantine cleric and Patriarch of Constantinople in exile at the Empire of Nicaea.
Originally serving as Metropolitan of Ephesus, he was elected to the patriarchate after the resignation of Arsenios Autoreianos in 1260. He died after a few months, in early 1261, and was buried at Nymphaion. A period of vacancy followed his death, but after the reconquest of Constantinople in July, Arsenios was recalled from his retirement and restored to the patriarchal throne.