| Pashashibou River | |
| Name Other: | Rivière Pashashibou |
| Pushpin Map: | Quebec |
| Subdivision Type1: | Country |
| Subdivision Name1: | Canada |
| Subdivision Type2: | Province |
| Subdivision Name2: | Quebec |
| Subdivision Type3: | Region |
| Subdivision Name3: | Côte-Nord |
| Subdivision Type4: | RCM |
| Subdivision Name4: | Minganie |
| Source1: | Lake Costebelle |
| Mouth: | Gulf of Saint Lawrence |
The Pashashibou River (French: '''Rivière Pashashibou''') is a river in the Côte-Nord region of Quebec, Canada. It flows into the Gulf of Saint Lawrence.
The Pashashibou River rises in Lake Costebelle and flows south for to Pashashibou Bay on the Gulf of Saint Lawrence.The river is scarcely navigable in a canoe for the first from its mouth, and then becomes no more than a stream.Its mouth is about west of Natashquan.The mouth of the Pashashibou River is in the municipality of Aguanish in the Minganie Regional County Municipality.
The shoreline extending to both sides of the river mouth is protected by the Pashashibou Bay Waterfowl Concentration Area (Aire de concentration d'oiseaux aquatiques de la Baie Pashashibou), an IUCN Management Category IV region designated in 2005 and managed by the Ministry of Forests, Wildlife and Parks.
The Innu of Natashquan call the river Pihu Hipu, which means "river with a lynx".Jacques Cartier named the bay Havre sainct Nicollas in 1535.The present name is derived from the Innu language term pishi-shebau.This can be interpreted as meaning "sharp rock" or "dry river".
The Dictionnaire des rivières et lacs de la province de Québec (1914) says,
Part of the river basin is in the unorganized territory of Lac-Jérôme and part in the municipality of Aguanish.The river basin covers .It lies between the basins of the Little Watshishou River to the west and the Nabisipi River to the east.A map of the ecological regions of Quebec shows the river basin in sub-regions 6j-T and 6m-T of the east spruce/moss subdomain.