Paromamine 6'-oxidase explained

Paromamine 6'-oxidase
Ec Number:	1.1.3.43

Paromamine 6'-oxidase (btrQ (gene), neoG (gene), kanI (gene), tacB (gene)) is an enzyme with systematic name paromamine:oxygen 6'-oxidoreductase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

paromamine + O₂

\rightleftharpoons 6'-dehydroparomamine + H₂O₂

This enzymes participates in biosynthesis of several aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.

Notes and References

1. Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB . Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin . ChemBioChem . 8 . 3 . 283–8 . February 2007 . 17206729 . 10.1002/cbic.200600371 .
2. Yu Y, Hou X, Ni X, Xia H . Biosynthesis of 3'-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption . The Journal of Antibiotics . 61 . 2 . 63–9 . February 2008 . 18408324 . 10.1038/ja.2008.111 . free .
3. Clausnitzer D, Piepersberg W, Wehmeier UF . The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin . Journal of Applied Microbiology . 111 . 3 . 642–51 . September 2011 . 21689223 . 10.1111/j.1365-2672.2011.05082.x . free .