Parathyroid hormone receptor explained

parathyroid hormone 1 receptor
Hgncid:	9608
Symbol:	PTH1R
Altsymbols:	PTHR, PFE
Entrezgene:	5745
Omim:	168468
Refseq:	NM_000316
Uniprot:	Q03431
Chromosome:	3
Arm:	p
Band:	22
Locussupplementarydata:	-p21.1

parathyroid hormone 2 receptor
Hgncid:	9609
Symbol:	PTH2R
Entrezgene:	5746
Omim:	601469
Refseq:	NM_005048
Uniprot:	P49190
Chromosome:	2
Arm:	q
Band:	33

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.^[1]

• parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.^{[2] [3]}
• parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.^[4]

External links

• • Web site: Parathyroid Hormone Receptors . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology .

Notes and References

1. Jüppner H . Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors . Curr. Opin. Nephrol. Hypertens. . 3 . 4 . 371–8 . 1994 . 8076140 . 10.1097/00041552-199407000-00002 .
2. Mannstadt M, Jüppner H, Gardella TJ . Receptors for PTH and PTHrP: their biological importance and functional properties . Am. J. Physiol. . 277 . 5 Pt 2 . F665–75 . 1999 . 10564229 . 10.1152/ajprenal.1999.277.5.F665. 2007-11-01 . https://web.archive.org/web/20090213101535/http://ajprenal.physiology.org/cgi/content/abstract/277/5/F665 . 2009-02-13 . dead .
3. Offermanns S, Iida-Klein A, Segre GV, Simon MI . G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells . Mol. Endocrinol. . 10 . 5 . 566–74 . 1996 . 10.1210/mend.10.5.8732687 . 8732687 . free .
4. Usdin TB, Bonner TI, Hoare SR . The parathyroid hormone 2 (PTH2) receptor . Recept. Channels . 8 . 3–4 . 211–8 . 2002 . 12529938 . 10.1080/10606820213682 .