Parvulin 17 Explained

Par17, a member of the parvulin family of peptidyl-prolyl-cis/trans-isomerases (PPIases), is an isoform of parvulin 14 (Par14) and originates from alternative transcription initiation of the PIN4 gene on chromosome Xq13 in humans.^{[1] [2]} Par17, which carries a 25 residue N-terminal extension, shares the complete successive amino acid sequence with Par14. In contrast to Par14, Par17 is exclusively expressed in Hominidae, as ORFs were only found within the genomes of orangutans, gorillas, chimpanzees and humans.^[3] The N-terminal extension seems to be responsible for the translocation of Par17 to the mitochondrial matrix.^[4] Par17 is involved in tubulin^{[5] [6]} and actin^[7] polymerization as well as in hepatitis B virus replication.^[8] Using photoaffinity labeling and liquid chromatography–mass spectrometry analysis, Par17 was found to be associated with mitochondrial proteins such as members of the electron transport chain in human cells.^[7]

References

1. 10.1186/1471-2199-7-9 . 2006 . Mueller . Jonathan . Kessler . Daniel . Neumann . Daniel . Stratmann . Tina . Papatheodorou . Panagiotis . Hartmann-Fatu . Cristina . Bayer . Peter . Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation . BMC Molecular Biology . 7 . 9 . 16522211 . 1420321 . free .
2. 10.1515/hsz-2017-0137 . Structure and function of the human parvulins Pin1 and Par14/17 . 2018 . Matena . Anja . Rehic . Edisa . Hönig . Dana . Kamba . Bianca . Bayer . Peter . Biological Chemistry . 399 . 2 . 101–125 . 29040060 . 46851627 . free .
3. 10.1186/1741-7007-5-37 . The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae . 2007 . Kessler . Daniel . Papatheodorou . Panagiotis . Stratmann . Tina . Dian . Elke . Hartmann-Fatu . Cristina . Rassow . Joachim . Bayer . Peter . Mueller . Jonathan . BMC Biology . 5 . 37 . 17875217 . 2031878 . free .
4. 10.1186/1741-7007-5-37 . The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae . 2007 . Kessler . Daniel . Papatheodorou . Panagiotis . Stratmann . Tina . Dian . Elke . Hartmann-Fatu . Cristina . Rassow . Joachim . Bayer . Peter . Mueller . Jonathan . BMC Biology . 5 . 37 . 17875217 . 2031878 . free .
5. 10.1016/j.jmb.2011.06.040 . Parvulin 17 Promotes Microtubule Assembly by Its Peptidyl-Prolyl Cis/Trans Isomerase Activity . 2011 . Thiele . Alexandra . Krentzlin . Karolin . Erdmann . Frank . Rauh . David . Hause . Gerd . Zerweck . Johannes . Kilka . Susann . Pösel . Stephanie . Fischer . Gunter . Schutkowski . Mike . Weiwad . Matthias . Journal of Molecular Biology . 411 . 4 . 896–909 . 21756916 .
6. 10.1074/jbc.M114.593228 . Parvulin 17-catalyzed Tubulin Polymerization is Regulated by Calmodulin in a Calcium-dependent Manner . 2015 . Burgardt . Noelia Inés . Schmidt . Andreas . Manns . Annika . Schutkowski . Alexandra . Jahreis . Günther . Lin . Yi-Jan . Schulze . Bianca . Masch . Antonia . Lücke . Christian . Weiwad . Matthias . Journal of Biological Chemistry . 290 . 27 . 16708–16722 . 25940090 . 4505421 . free .
7. 10.1515/hsz-2019-0423 . Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerization . 2020 . Goehring . Anna . Michin . Irina . Gerdes . Tina . Schulze . Nina . Blueggel . Mike . Rehic . Edisa . Kaschani . Farnusch . Kaiser . Markus . Bayer . Peter . Biological Chemistry . 401 . 8 . 955–968 . 32142471 . 212621904 .
8. 10.1128/JVI.01840-18 . Parvulin 14 and Parvulin 17 Bind to HBX and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBX-Dependent Manner . 2018 . Saeed . Umar . Kim . Jumi . Piracha . Zahra Zahid . Kwon . Hyeonjoong . Jung . Jaesung . Chwae . Yong-Joon . Park . Sun . Shin . Ho-Joon . Kim . Kyongmin . Journal of Virology . 93 . 6 . 30567987 . 6401437 .