| Pánuco | |
| Settlement Type: | City & municipal seat |
| Mapsize: | 300px |
| Pushpin Map: | Mexico |
| Pushpin Label Position: | above |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Veracruz |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | Pánuco |
| Leader Title: | Municipal President |
| Leader Name: | Oscar Guzmán de Paz |
| Established Title: | Founded |
| Established Date: | 22 December 1522 |
| Established Title2: | City status |
| Established Date2: | 30 June 1931 |
| Population As Of: | 2005 |
| Population Total: | 33,122 |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Coordinates: | 22.05°N -98.1833°W |
| Elevation M: | 10 |
| Postal Code Type: | Postal code |
| Area Code: | 846 |
| Blank Name: | Demonym |
| Website: | www.panuco.gob.mx |
Pánuco (pronounced as /es/) is a city in the Mexican state of Veracruz, located in the state's Huasteca Alta region. It serves as the municipal seat of the surrounding Pánuco Municipality. It stands on the banks of the Río Pánuco.
In the 2005 INEGI Census, the city of Pánuco reported a total population of 33,122.[1]
Pánuco is traditionally held to have been founded by Hernán Cortés on 22 December 1522, as Villa de Santiesteban del Puerto, the second ayuntamiento on the American continent. It was the capital of the Province of Pánuco in the early colonial period. It was given city status on 30 June 1931.
Hernando de Soto's 1541 expedition stopped in Panuco after his death.
On April 23, 1900, Pánuco was destroyed by fire, leaving more than 2,000 homeless.[2]