Panther Creek is a stream in Gentry and Harrison counties of northern Missouri. It is a tributary of the East Fork Grand River.
The stream headwaters in Harrison County are located at 40.3925°N -94.1525°W and the confluence with the East Fork is at 40.3017°N -94.3478°W.
According to tradition, Panther Creek was so named on account of some pioneers encountering panthers along its course.[1]