Panipenem/betamipron explained

Type:	combo
Component1:	Panipenem
Class1:	Carbapenem antibiotic
Component2:	Betamipron
Class2:	Inhibitor of renal panipenem uptake
Tradename:	Carbenin
Routes Of Administration:	Intravenous
Cas Number:	138240-65-0
Atc Prefix:	J01
Atc Suffix:	DH55
Pubchem:	115235
Kegg:	D02509

Panipenem/betamipron is a carbapenem antibiotic^[1] marketed by Daiichi Sankyo Co. of Japan. It was launched in 1993,^[2] under the brand name Carbenin.^[3]

It is a combination in which panipenem is the carbapenem antibiotic and betamipron inhibits renal uptake of panipenem^[4] and so reduces its nephrotoxicity^[5] (much like the imipenem/cilastatin combination).

Notes and References

1. Hikida M, Terashima S, Sato Y, Okamoato R, Inoue M . [Comparative antibacterial activity of carbapenems against P. aeruginosa (1)] ]. The Japanese Journal of Antibiotics . 54 . 11 . 571–9 . November 2001 . 11828603 . 10.11553/antibiotics1968b.54.571 .
2. Web site: Sankyo Launch. 1994-01-24. The Pharmaletter.

3. Carbenin.

4. Book: Finch, Roger G. . vanc . Antibiotic and chemotherapy: anti-infective agents and their use in therapy. 8 August 2011. 2003. Elsevier Health Sciences. 978-0-443-07129-4. 269ff.
5. Goa KL, Noble S . Panipenem/betamipron . Drugs . 63 . 9 . 913–25; discussion 926 . 2003 . 12678575 . 10.2165/00003495-200363090-00005 . 263994230 .