| Panhandle Regional Planning Commission | |
| Map: | Texas Panhandle.PNG |
| Mcaption: | Map of Texas highlighting counties served by the Panhandle Regional Planning Commission |
| Formation: | 1969 |
| Type: | Voluntary association of governments |
| Region Served: | 26000sqmi |
| Membership: | 26 counties |
The Panhandle Regional Planning Commission (PRPC) is a voluntary association of cities, counties and special districts in the Texas Panhandle.
Based in Amarillo, the Panhandle Regional Planning Commission is a member of the Texas Association of Regional Councils.