Pancreatic polypeptide receptor 1 explained

Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene.^{[1] [2] [3]}

Selective Ligands

Agonists

• Pancreatic polypeptide
• Neuropeptide Y (endogenous agonist, non subtype selective)
• Peptide YY
• GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Antagonists

• UR-AK49^[4]

See also

• Neuropeptide Y receptor

External links

• Web site: Neuropeptide Y Receptors: Y₄ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2016-03-03 . https://web.archive.org/web/20160303173645/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2370 . dead .

Further reading

• Keire DA, Bowers CW, Solomon TE, Reeve JR . Structure and receptor binding of PYY analogs . Peptides . 23 . 2 . 305–321 . February 2002 . 11825645 . 10.1016/S0196-9781(01)00602-7 . 7082920 .
• Balasubramaniam A . Clinical potentials of neuropeptide Y family of hormones . American Journal of Surgery . 183 . 4 . 430–434 . April 2002 . 11975932 . 10.1016/S0002-9610(02)00803-6 .
• Parker E, Van Heek M, Stamford A . Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status . European Journal of Pharmacology . 440 . 2–3 . 173–187 . April 2002 . 12007534 . 10.1016/S0014-2999(02)01427-9 .
• Benaim G, Villalobo A . Phosphorylation of calmodulin. Functional implications . European Journal of Biochemistry . 269 . 15 . 3619–3631 . August 2002 . 12153558 . 10.1046/j.1432-1033.2002.03038.x . free . 10261/79981 .
• Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D . 6 . Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY . The Journal of Biological Chemistry . 270 . 49 . 29123–29128 . December 1995 . 7493937 . 10.1074/jbc.270.49.29123 . free .
• Bard JA, Walker MW, Branchek TA, Weinshank RL . Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY . The Journal of Biological Chemistry . 270 . 45 . 26762–26765 . November 1995 . 7592911 . 10.1074/jbc.270.45.26762 . free .
• Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W . Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors . Proceedings of the National Academy of Sciences of the United States of America . 93 . 10 . 4661–4665 . May 1996 . 8643460 . 39335 . 10.1073/pnas.93.10.4661 . free . 1996PNAS...93.4661Y .
• Kawabe T, Muslin AJ, Korsmeyer SJ . HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint . Nature . 385 . 6615 . 454–458 . January 1997 . 9009195 . 10.1038/385454a0 . 608633 . 1997Natur.385..454K .
• Darby K, Eyre HJ, Lapsys N, Copeland NG, Gilbert DJ, Couzens M, Antonova O, Sutherland GR, Jenkins NA, Herzog H . 6 . Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14 . Genomics . 46 . 3 . 513–515 . December 1997 . 9441761 . 10.1006/geno.1997.5071 . Grant Robert Sutherland .
• Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P . Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1 . Biochemistry . 38 . 14 . 4365–4373 . April 1999 . 10194355 . 10.1021/bi982900m .
• Smith FD, Oxford GS, Milgram SL . Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein . The Journal of Biological Chemistry . 274 . 28 . 19894–19900 . July 1999 . 10391935 . 10.1074/jbc.274.28.19894 . free .
• Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR . PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts . Cell . 101 . 4 . 365–376 . May 2000 . 10830164 . 10.1016/S0092-8674(00)80847-8 . 6496567 . free .
• Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S . Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1 . Molecular and Cellular Biology . 21 . 20 . 6841–6850 . October 2001 . 11564868 . 99861 . 10.1128/MCB.21.20.6841-6850.2001 .
• Cavadas C, Silva AP, Mosimann F, Cotrim MD, Ribeiro CA, Brunner HR, Grouzmann E . NPY regulates catecholamine secretion from human adrenal chromaffin cells . The Journal of Clinical Endocrinology and Metabolism . 86 . 12 . 5956–5963 . December 2001 . 11739470 . 10.1210/jcem.86.12.8091 . free . 10316/12627 . free .
• Cox HM, Tough IR . Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa . British Journal of Pharmacology . 135 . 6 . 1505–1512 . March 2002 . 11906964 . 1573267 . 10.1038/sj.bjp.0704604 .
• Wu DY, Tkachuck DC, Roberson RS, Schubach WH . The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity . The Journal of Biological Chemistry . 277 . 31 . 27706–27715 . August 2002 . 12016208 . 10.1074/jbc.M200955200 . free .

Notes and References

1. Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA . Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY . Genomics . 46 . 2 . 287–290 . December 1997 . 9417917 . 10.1006/geno.1997.5024 . free .
2. Web site: Entrez Gene: PPYR1 pancreatic polypeptide receptor 1.
3. Al-hussaniy HA, AL-Biati HA . 2022-12-02 . The Role of Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio in Obesogenesis: Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio . Medical and Pharmaceutical Journal . en . 1 . 2 . 10.55940/medphar20227 . 2957-6067. free .
4. Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A . Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence . Journal of Receptor and Signal Transduction Research . 27 . 4 . 217–233 . 2007 . 17885919 . 10.1080/10799890701505206 . 26579625 .