Panagiotopoulos or Panayotopoulos (Παναγιωτόπουλος) is a Greek surname, meaning "son of Panagiotis" and "son of Panagiotou". The feminine form is Panagiotopoulou/Panayotopoulou (Παναγιωτοπούλου) meaning "son of Panagiotopoulos". Notable people with the surname include: