Pam Sykes Explained

Pamela Sykes is an Australian medical scientist, Emeritus Professor at the College of Medicine and Public Health and Chair of the Institutional Biosafety Committee at the Flinders Centre for Innovation in Cancer at Flinders University. She is a Strategic Professor in the area of Preventive Cancer Biology and leads a research group which studies the biological effects of low-dose radiation. She is a member of the Radiation Protection Committee which advises the Government of South Australia. Her research has been published in Radiation Research, Epigenetics, Transgenic Research, Cell Biology and Toxicology, PLOS ONE, Mutation Research and the Journal of Clinical Pathology. She is an Associate Editor for the journal Radiation Research.^[1] Sykes' research into the effects of low-dose ionising radiation has been funded by the United States Department of Energy's Low Dose Radiation Research Program since the early 2000s.^{[2] [3]}

As of 2016, Sykes is a member of the UCL Australia Nuclear Working Group.^{[4] [5]}

Selected Publications

• Until There Is a Resolution of the Pro-LNT/Anti-LNT Debate, We Should Head Toward a More Sensible Graded Approach for Protection From Low-Dose Ionizing Radiation, 2020.^[6]
• The combination of metformin and valproic acid has a greater anti-tumoral effect on prostate cancer growth in vivo than either drug alone, Flinders University, 2019.
• Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide, 2018.^[7]
• MP83-08 combination of metformin and sodium valproate for prostate cancer: a rapid approach from bench to clinical trial, 2017.^[8]

References

1. Web site: Flinders University. www.flinders.edu.au. 2016-11-02.
2. Web site: Ignorance Drives Radiation Fears. 2011-06-05. fmcfoundation.com.au. Flinders Foundation. 2016-11-02.
3. Web site: Radiation response a meltdown in reason. 2011-07-14. blogs.flinders.edu.au. Flinders University. 2016-11-02.
4. News: Nuclear Working Group UCL Australia. UCL Australia. en-GB. 2016-11-02.
5. News: Pam Sykes - UCL Australia. UCL Australia. en-GB. 2016-11-02.
6. Sykes . Pamela J. . 2020-04-01 . Until There Is a Resolution of the Pro-LNT/Anti-LNT Debate, We Should Head Toward a More Sensible Graded Approach for Protection From Low-Dose Ionizing Radiation . Dose-Response . en . 18 . 2 . 155932582092165 . 10.1177/1559325820921651 . 1559-3258 . 7218310 . 32425725.
7. Morel . Katherine L. . Ormsby . Rebecca J. . Solly . Emma L. . Tran . Linh N. K. . Sweeney . Christopher J. . Klebe . Sonja . Cordes . Nils . Sykes . Pamela J. . 2018-10-01 . Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide . Clinical & Experimental Metastasis . en . 35 . 7 . 649–661 . 10.1007/s10585-018-9915-9 . 1573-7276.
8. Tran . Linh N.K. . Kichenadasse . Ganessan . Ormsby . Rebecca J. . Morel . Katherine L. . Butler . Lisa M. . Centenera . Margaret M. . Sykes . Pamela J. . April 2017 . MP83-08 Combination of Metformin and Sodium Valproate for Prostate Cancer: A Rapid Approach From Bench to Clinical Trial. . Journal of Urology . 197 . 4S . 10.1016/j.juro.2017.02.2576 . 0022-5347.