| Pamekasan | |
| Native Name: | Mekkasân |
| Settlement Type: | Town |
| Pushpin Map: | Indonesia_Java#Indonesia |
| Pushpin Label Position: | left |
| Pushpin Map Caption: | Location in Java and Indonesia |
| Subdivision Type: | Country |
| Subdivision Name: |  Indonesia |
| Subdivision Type1: | Province |
| Subdivision Type2: | Regency |
| Subdivision Name2: | Pamekasan Regency |
| Unit Pref: | Metric |
| Area Footnotes: | [1] |
| Area Total Km2: | 26.47 |
| Population As Of: | mid 2023 estimate |
| Population Footnotes: | [2] |
| Population Total: | 91160 |
| Population Density Km2: | auto |
| Timezone1: | Indonesia Western Time |
| Utc Offset1: | +7 |
| Postal Code Type: | Postcodes |
| Postal Code: | 69311,69312, 69314, 69316, 69317 |
| Area Code Type: | Area code |
| Area Code: | (+62) 324 |
| Blank Name: | Villages |
| Blank Info: | 18 |
Pamekasan (Madurese: Mekkasân) is a town and district which serves as the administrative center of Pamekasan Regency, East Java Province, Indonesia. It is located on the island of Madura, in an inland location towards the south coast of the island.
Pamekasan consists of 18 villages (Kelurahan or Desa) namely:
Nine of the above (indicated by asterisks) are classed as urban (kelurahan) and nine as rural (desa).
Pamekasan has a tropical savanna climate (Aw) with moderate to little rainfall from May to November and heavy rainfall from December to April.