| Palazzuolo sul Senio | |
| Official Name: | Comune di Palazzuolo sul Senio |
| Native Name: | Palazzuolo di Romagna |
| Coordinates: | 44.1167°N 44°W |
| Region: | Tuscany |
| Metropolitan City: | Florence (FI) |
| Frazioni: | Campanara, Casetta di Tiara, Mantigno, Misileo, Piedimonte, Quadalto, Salecchio, Visano |
| Mayor: | Marco Bottino |
| Area Total Km2: | 109.11 |
| Population Footnotes: | [1] |
| Population Total: | 1081 |
| Population As Of: | 1 January 2024 |
| Population Demonym: | Palazzuolesi |
| Elevation M: | 437 |
| Istat: | 048031 |
| Saint: | St. Stephen |
| Day: | December 26 |
| Postal Code: | 50035 |
| Area Code: | 055 |
Palazzuolo sul Senio (formerly Palazzolo di Romagna; Romagnolo: Palazol) is a comune (municipality) in the Metropolitan City of Florence in the Italian region Tuscany, located about 45km (28miles) northeast of Florence.
Palazzuolo sul Senio borders the following municipalities: Borgo San Lorenzo, Brisighella, Casola Valsenio, Castel del Rio, Firenzuola, Marradi.
Since 2018, it has been designated as one of I Borghi più belli d'Italia ("The most beautiful villages of Italy").[2]