| Native Name: | German: Pfalz-Mosbach |
| Conventional Long Name: | Palatinate-Mosbach |
| Status: | vassal |
| Empire: | Holy Roman Empire |
| Capital: | Mosbach |
| Year Start: | 1410 |
| Event Start: | Partitioned from the Palatinate |
| Year End: | 1448 |
| Event End: | United with Palatinate-Neumarkt |
| P1: | Electoral Palatinate |
| S1: | Palatinate-Mosbach-Neumarkt |
Palatinate-Mosbach was a state of the Holy Roman Empire centred on Mosbach and Eberbach in the north of modern Baden-Württemberg, Germany.
Palatinate-Mosbach was created in 1410 out of the partition of the Palatinate after the death of King Rupert III for his son Otto. In 1448 Otto inherited half of Palatinate-Neumarkt, purchased the other half, and renamed his state Palatinate-Mosbach-Neumarkt.