| Palace of Santoña | |
| Native Name: | Palacio de Santoña |
| Native Language: | Spanish |
| Coordinates: | 40.414°N -3.7004°W |
| Location: | Madrid, Spain |
| Designation1: | Spain |
| Designation1 Offname: | Palacio de Santoña |
| Designation1 Type: | Non-movable |
| Designation1 Criteria: | Monument |
| Designation1 Date: | 1995 |
| Designation1 Number: | RI-51-0009081 |
The Spanish; Castilian: Palacio de Santoña|italics=no (English: Palace of Santoña) is a palace located in Madrid, Spain, originally constructed for the Duke of Santoña. It was declared Bien de Interés Cultural in 1995. It is a sixteenth century building, renovated in the eighteenth century by the architect Pedro de Ribera, and in the nineteenth century by .
The Candidates Tournament 2022 in chess was held at the Palacio from June - July 2022.[1]