Paeonol Explained

Paeonol is a phenolic compound found in peonies[1] such as Paeonia suffruticosa (moutan cortex),[2] [3] in Arisaema erubescens,[4] and in Dioscorea japonica.[5] It is a chemical compound found in some traditional Chinese medicines.[6]

Biological effects

A number of biological effects of paeonol in vitro or in animal models have been observed. Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease.[7] Paeonol also reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats.[8]

Paeonol shows antimutagenic activities.[2] [5] It also has anti-inflammatory and analgesic effects in carrageenan-evoked thermal hyperalgesia.[9] Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α.[10]

Paeonol has weak MAO-A and MAO-B inhibiting effects with IC50 values of 54.6 μM and 42.5 μM respectively.[11]

Metal complex

Metal complexes of paeonol shows tetrahedral and octahedral coordination geometry in the absence and presence of solvent pyridine respectively.[12]

Notes and References

  1. Zhang, L., Li, D. C., & Liu, L. F. (2019). Paeonol: pharmacological effects and mechanisms of action. International immunopharmacology, 72, 413-421.
  2. Paeonol: a bio-antimutagen isolated from a crude drug, moutan cortex. Fukuhara Y, Yoshida D. amp . Agricultural and Biological Chemistry. 1987. 51. 5. 1441–1442. . 10.1271/bbb1961.51.1441 . free.
  3. 10.1002/bmc.259. Determination of paeonol in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies following oral administration of Moutan cortex decoction. 2003. Wu. Xinan. Chen. Hongli. Chen. Xingguo. Hu. Zhide. Biomedical Chromatography. 17. 8. 504–8. 14648606.
  4. Isolation of paeonol from Arisaema erubescens. Ducki S, Hadfield JA, Lawrence NJ, Zhang X, McGown AT. amp. Planta Medica. 1995. 61. . 6. 10.1055/s-2006-959390. 8824957. 586–587 .
  5. 10.1021/jf950792u. Antimutagenic Activity of (+)-β-Eudesmol and Paeonol fromDioscorea japonica. 1996. Miyazawa. Mitsuo. Shimamura. Hideo. Nakamura. Sei-Ichi. Kameoka. Hiromu. Journal of Agricultural and Food Chemistry. 44. 7. 1647–1650.
  6. 10.1016/j.chroma.2005.11.023. Development of microwave-assisted extraction followed by headspace single-drop microextraction for fast determination of paeonol in traditional Chinese medicines. 2006. Deng. Chunhui. Yao. Ning. Wang. Ben. Zhang. Xiangmin. Journal of Chromatography A. 1103. 15–21. 16309693. 1.
  7. 21377451. 10.1016/j.brainres.2011.02.064. Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease. 2011. Zhou. Jun. Zhou. Li. Hou. Deren. Tang. Jiaochun. Sun. Juanjuan. Bondy. Stephen C.. Brain Research. 1388. 141–7. 12668336 .
  8. 10.1016/j.jep.2005.12.027. Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. 2006. Hsieh. Ching-Liang. Cheng. Chin-Yi. Tsai. Tung-Hu. Lin. I-Hsin. Liu. Chung-Hsiang. Chiang. Su-Yin. Lin. Jaung-Geng. Lao. Chih-Jui. Tang. Nou-Ying. Journal of Ethnopharmacology. 106. 2. 208–15. 16458462.
  9. 10.1038/sj.bjp.0705360. Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. 2003. Chou. Tz-Chong. British Journal of Pharmacology. 139. 6. 1146–52. 12871833. 1573952.
  10. 10.1016/j.intimp.2003.12.013. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α. 2004. Kim. Sung Hoon. Kim. Seung-Ae. Park. Mi-Kyung. Kim. Seung-Hyung. Park. Young-Doo. Na. Ho-Jeong. Kim. Hyung-Min. Shin. Min-Kyu. Ahn. Kyoo-Seok. International Immunopharmacology. 4. 2. 279–87. 14996419.
  11. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones . Journal of Ethnopharmacology . 91 . 2–3 . 2004 . 351–355 . 10.1016/j.jep.2004.01.013 . Kong . L.D. . Cheng . Christopher H.K. . Tan . R.X. . 15120460 .
  12. Patel . Mahesh kumar . Solvent effect on neutral Co (II) complexes of paeonol derivative equalitative and quantitative studies from energy frame work and Hirshfeld surface analysis . Journal of Molecular Structure . 1196 . 119–131 . 10.1016/j.molstruc.2019.06.050 . 2019 . 2019JMoSt1196..119P . 197231895 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Paeonol".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.