PWP2 explained

Periodic tryptophan protein 2 homolog is a protein that in humans is encoded by the PWP2 gene.^{[1] [2]}

Function

This protein is involved in the assembly of small subunit of ribosome.^[2]

Further reading

• Lalioti MD . Cloning the cDNA of human PWP2, which encodes a protein with WD repeats and maps to 21q22.3 . Genomics . 35 . 2 . 321–7 . 1996 . 8661145 . 10.1006/geno.1996.0363 . vanc. Chen H . Rossier C . 3 . Shafaatian . Reza . Reid . John D. . Antonarakis . Stylianos E. .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Lafrenière RG . Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 (PWP2) gene mapping to 21q22.3 . Genome Res. . 6 . 12 . 1216–26 . 1997 . 8973917 . 10.1101/gr.6.12.1216 . vanc. Rochefort DL . Chrétien N . 3 . Neville . C E . Korneluk . R G . Zuo . L . Wei . Y . Lichter . J . Rouleau . G A . free .
• Nagamine K . Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3 . Biochem. Biophys. Res. Commun. . 235 . 1 . 185–90 . 1997 . 9196060 . 10.1006/bbrc.1997.6758 . vanc. Kudoh J . Kawasaki K . 3 . Minoshima . Shinsei . Asakawa . Shuichi . Ito . Fumiaki . Shimizu . Nobuyoshi .
• Nagamine K . Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21 . Genomics . 42 . 3 . 528–31 . 1997 . 9205129 . 10.1006/geno.1997.4761 . vanc. Kudoh J . Minoshima S . 3 . Kawasaki . Kazuhiko . Asakawa . Shuichi . Ito . Fumiaki . Shimizu . Nobuyoshi .
• Hattori M . The DNA sequence of human chromosome 21 . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . vanc. Fujiyama A . Taylor TD . 3 . Taylor . T. D. . Watanabe . H. . Yada . T. . Park . H.-S. . Toyoda . A. . Ishii . K. . 2000Natur.405..311H . free .
• Scherl A . Functional Proteomic Analysis of Human Nucleolus . Mol. Biol. Cell . 13 . 11 . 4100–9 . 2003 . 12429849 . 10.1091/mbc.E02-05-0271 . 133617 . vanc. Couté Y . Déon C . 3 . Callé . A . Kindbeiter . K . Sanchez . JC . Greco . A . Hochstrasser . D . Diaz . JJ .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Yamakawa K, Gao DQ, Korenberg JR . A periodic tryptophan protein 2 gene homologue (PWP2H) in the candidate region of progressive myoclonus epilepsy on 21q22.3 . Cytogenet Cell Genet . 74 . 1–2 . 140–5 . Dec 1996 . 8893822 . 10.1159/000134402 .
2. Web site: PWP2 PWP2 small subunit processome component [Homo sapiens (human) ]].