PURB explained

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.^{[1] [2]}

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans.

Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.

Further reading

• Toward a complete human genome sequence . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .
• Kelm RJ . Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter . J. Biol. Chem. . 274 . 20 . 14238–45 . 1999 . 10318844 . 10.1074/jbc.274.20.14238 . Cogan JG . Elder PK . Strauch . AR . Getz . MJ . free.
• Lezon-Geyda K, Najfeld V, Johnson EM . Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia . Leukemia . 15 . 6 . 954–62 . 2001 . 11417483 . 10.1038/sj.leu.2402108 . 7186291 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Scherer SW . Human Chromosome 7: DNA Sequence and Biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . Cheung J . MacDonald JR . Osborne . LR . Nakabayashi . K . Herbrick . JA . Carson . AR . Parker-Katiraee . L . Skaug . J . 2003Sci...300..767S .
• Hillier LW . The DNA sequence of human chromosome 7 . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . Fulton RS . Fulton LA . Graves . Tina A. . Pepin . Kymberlie H. . Wagner-Mcpherson . Caryn . Layman . Dan . Maas . Jason . Jaeger . Sara . 2003Natur.424..157H . free .
• Gupta M . Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure . J. Biol. Chem. . 278 . 45 . 44935–48 . 2004 . 12933792 . 10.1074/jbc.M307696200 . Sueblinvong V . Raman J . Jeevanandam . V . Gupta . MP . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . Jedrychowski M . Schwartz D . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . Blagoev B . Gnad F . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.

Notes and References

1. Bergemann AD, Ma ZW, Johnson EM . Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein . Mol Cell Biol . 12 . 12 . 5673–82 . Dec 1992 . 1448097 . 360507 . 10.1128/mcb.12.12.5673.
2. Web site: Entrez Gene: PURB purine-rich element binding protein B.