PUM2 explained

Pumilio homolog 2 is an RNA-binding protein that in humans is encoded by the PUM2 gene.^{[1] [2] [3] [4]}

Interactions

PUM2 has been shown to interact with the following proteins:

• CPEB^[5]
• DAZL^[6]
• DAZ1^[7]
• NANOS1^[8]

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Spik A, Oczkowski S, Olszak A, Kotecki M, Formanowicz P, Błazewicz J, Jaruzelska J . Candidate mRNAs interacting with fertility protein PUMILIO2 in the human germ line . Reproductive Biology . 6 . 37–42 . 2006 . Suppl 1 . 16967088 .
• Nakayama M, Kikuno R, Ohara O . Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs . Genome Res. . 12 . 11 . 1773–84 . 2003 . 12421765 . 187542 . 10.1101/gr.406902 .
• Jaruzelska J, Kotecki M, Kusz K, Spik A, Firpo M, Reijo Pera RA . Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells . Dev. Genes Evol. . 213 . 3 . 120–6 . 2004 . 12690449 . 10.1007/s00427-003-0303-2 . 19186730 .
• Dazard JE, Gal H, Amariglio N, Rechavi G, Domany E, Givol D . Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer . Oncogene . 22 . 19 . 2993–3006 . 2003 . 12771951 . 10.1038/sj.onc.1206537 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Fox M, Urano J, Reijo Pera RA . Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind . Genomics . 85 . 1 . 92–105 . 2005 . 15607425 . 10.1016/j.ygeno.2004.10.003 .
• Scott RE, White-Grindley E, Ruley HE, Chesler EJ, Williams RW . P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA . J. Cell. Physiol. . 204 . 1 . 99–105 . 2005 . 15617101 . 10.1002/jcp.20263 . 24888360 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Kusz K, Ginter-Matuszewska B, Ziolkowska K, Spik A, Bierla J, Jedrzejczak P, Latos-Bielenska A, Pawelczyk L, Jaruzelska J . Polymorphisms of the human PUMILIO2 gene and male sterility . Mol. Reprod. Dev. . 74 . 6 . 795–9 . 2007 . 17154300 . 10.1002/mrd.20683 . 6213126 .

Notes and References

1. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain . DNA Res . 3 . 5 . 321–9, 341–54 . May 1997 . 9039502 . 10.1093/dnares/3.5.321 . free .
2. Spassov DS, Jurecic R . Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins . Gene . 299 . 1–2 . 195–204 . Dec 2002 . 12459267 . 10.1016/S0378-1119(02)01060-0 .
3. Moore FL, Jaruzelska J, Fox MS, Urano J, Firpo MT, Turek PJ, Dorfman DM, Pera RA . Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-Like proteins . Proc Natl Acad Sci U S A . 100 . 2 . 538–43 . Jan 2003 . 12511597 . 141031 . 10.1073/pnas.0234478100 . 2003PNAS..100..538M . free .
4. Web site: Entrez Gene: PUM2 pumilio homolog 2 (Drosophila).
5. Campbell ZT, Menichelli E, Friend K, Wu J, Kimble J, Williamson JR, Wickens M . Identification of a conserved interface between PUF and CPEB proteins. . J Biol Chem . 287 . 22 . 18854–62 . 2012 . 22496444 . 10.1074/jbc.M112.352815 . 3365739. free .
6. Ota R, Kotani T, Yamashita M . Biochemical characterization of Pumilio1 and Pumilio2 in Xenopus oocytes. . J Biol Chem . 286 . 4 . 2853–63 . 2011 . 21098481 . 10.1074/jbc.M110.155523 . 3024781. free .
7. Haston KM, Tung JY, Reijo Pera RA . Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro. . PLOS ONE . 4 . 5 . e5654 . 2009 . 19468308 . 10.1371/journal.pone.0005654 . 2681483. 2009PLoSO...4.5654H . free .
8. Geyer CB, Saba R, Kato Y, Anderson AJ, Chappell VK, Saga Y, Eddy EM . Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male. . Biol Reprod . 86 . 4 . 127 . 2012 . 22190708 . 10.1095/biolreprod.111.094938 . 3338663.