PTS Galactitol Family explained

The PTS Galactitol (Gat) Family (TC# 4.A.5) is part of the PTS-AG superfamily. The biochemistry of this family is poorly defined. The only well-characterized member of this family is the galactitol permease of Escherichia coli.^[1] However, a homologous IIC protein from Listeria monocytogenes has been shown to be required for D-arabitol fermentation.^[2] It presumably functions together with IIA^Gat and IIB^Gat homologues. IIC^Gat is distantly related to IIC^Sgc of E. coli; IIA^Gat is distantly related to IIA^Sga and IIA^Sgcof E. coli as well as IIA^Mtl and IIA^Fru. IIB^Gat is distantly related to IIB^Sga and IIB^Sgc of E. coli.^[3] Domains in the LicR/CelR family of transcriptional activators show C-terminal domains exhibiting weak sequence similarity to IIB^Gat and IIA^Gat.^[4]

Notes and References

1. Nobelmann. Barbara. 17 May 1995. Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli.. Biochim Biophys Acta. 1262. 1 . 10.1016/0167-4781(95)00053-j. 7772602. 69–72.
2. Saklani-Jusforgues. H.. Fontan. E.. Goossens. P. L.. 2001-03-01. Characterisation of a Listeria monocytogenes mutant deficient in D-arabitol fermentation. Research in Microbiology. 152. 2. 175–177. 0923-2508. 11316371. 10.1016/s0923-2508(01)01189-5. free.
3. Reizer. Jonathan. Apr 1995. Novel phosphotransferase system genes revealed by bacterial genome analysis--a gene cluster encoding a unique Enzyme I and the proteins of a fructose-like permease system. Microbiology. 141. 4. 10.1099/13500872-141-4-961. 7773398. 961–71. free.
4. Tchieu. J. H.. Norris. V.. Edwards. J. S.. Saier. M. H.. 2001-07-01. The complete phosphotransferase system in Escherichia coli. Journal of Molecular Microbiology and Biotechnology. 3. 3. 329–346. 1464-1801. 11361063.