PTS-GFL superfamily explained

The phosphotransferases system (PTS-GFL) superfamily is a superfamily of phosphotransferase enzymes that facilitate the transport of glucose, glucitol (G), fructose (F) and lactose (L). Classification has been established through phylogenic analysis and bioinformatics.^{[1] [2]}

The bacterial phosphoenolpyruvate:sugar phosphotransferase system (PTS) transports and phosphorylates its sugar substrates in a single energy-coupled step. This transport process is dependent on several cytoplasmic phosphoryl transfer proteins - Enzyme I (I), HPr, Enzyme IIA (IIA), and Enzyme IIB (IIB)) as well as the integral membrane sugar permease (IIC). The PTS Enzyme II complexes are derived from independently evolving 4 PTS Enzyme II complex superfamilies, that include the (1) Glucose (Glc),(2) Mannose (Man), (3) Ascorbate-Galactitol (Asc-Gat) and (4) Dihydroxyacetone (Dha) superfamilies.

The four families that make up the PTS-GFL superfamily include:

• 4.A.1 – The PTS Glucose-Glucoside (Glc) Family
• 4.A.2 – The PTS Fructose-Mannitol (Fru) Family
• 4.A.3 – The PTS Lactose-N,N'-Diacetylchitobiose-β-glucoside (Lac) Family
• 4.A.4 – The PTS Glucitol (Gut) Family

See also

• Phosphotransferases system

Further reading

• "TCDB - PTS-GFL Superfamily". www.tcdb.org.
• Chang, Abraham B.; Lin, Ron; Keith Studley, W.; Tran, Can V.; Saier, Milton H. (2004-06-01). "Phylogeny as a guide to structure and function of membrane transport proteins". Molecular Membrane Biology 21 (3): 171–181.doi:10.1080/09687680410001720830. ISSN 0968-7688.PMID 15204625.

Notes and References

1. Chen. Jonathan S.. Reddy. Vamsee. Chen. Joshua H.. Shlykov. Maksim A.. Zheng. Wei Hao. Cho. Jaehoon. Yen. Ming Ren. Saier. Milton H.. 2012-01-01. Phylogenetic Characterization of Transport Protein Superfamilies: Superiority of SuperfamilyTree Programs over Those Based on Multiple Alignments. Journal of Molecular Microbiology and Biotechnology. 21. 3–4. 83–96. 10.1159/000334611. 1464-1801. 3290041. 22286036.
2. Nguyen. Thai X.. Yen. Ming-Ren. Barabote. Ravi D.. Saier. Milton H.. 2006-01-01. Topological predictions for integral membrane permeases of the phosphoenolpyruvate:sugar phosphotransferase system. Journal of Molecular Microbiology and Biotechnology. 11. 6. 345–360. 10.1159/000095636. 1464-1801. 17114898.