PTPRJ explained

Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.

Interactions

PTPRJ has been shown to interact with CTNND1.^[4]

Further reading

• Harrod TR, Justement LB . Evaluating function of transmembrane protein tyrosine phosphatase CD148 in lymphocyte biology . Immunol. Res. . 26 . 1–3 . 153–66 . 2003 . 12403354 . 10.1385/IR:26:1-3:153 . 26502472 .
• Jallal B, Mossie K, Vasiloudis G, Knyazev P, Zachwieja J, Clairvoyant F, Schilling J, Ullrich A . The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase . J. Biol. Chem. . 272 . 18 . 12158–63 . 1997 . 9115287 . 10.1074/jbc.272.18.12158 . free .
• de la Fuente-García MA, Nicolás JM, Freed JH, Palou E, Thomas AP, Vilella R, Vives J, Gayá A . CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes . Blood . 91 . 8 . 2800–9 . 1998 . 9531590 . 10.1182/blood.V91.8.2800.2800_2800_2809. free .
• Tangye SG, Phillips JH, Lanier LL, de Vries JE, Aversa G . CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation . J. Immunol. . 161 . 7 . 3249–55 . 1998 . 10.4049/jimmunol.161.7.3249 . 9759839 . free .
• Gross S, Knebel A, Tenev T, Neininger A, Gaestel M, Herrlich P, Böhmer FD . Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction . J. Biol. Chem. . 274 . 37 . 26378–86 . 1999 . 10473595 . 10.1074/jbc.274.37.26378 . free .
• Autschbach F, Palou E, Mechtersheimer G, Rohr C, Pirotto F, Gassler N, Otto HF, Schraven B, Gaya A . Expression of the membrane protein tyrosine phosphatase CD148 in human tissues . Tissue Antigens . 54 . 5 . 485–98 . 2000 . 10599888 . 10.1034/j.1399-0039.1999.540506.x .
• Billard C, Delaire S, Raffoux E, Bensussan A, Boumsell L . Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage . Blood . 95 . 3 . 965–72 . 2000 . 10648410 . 10.1182/blood.V95.3.965.003k39_965_972.
• Kovalenko M, Denner K, Sandström J, Persson C, Gross S, Jandt E, Vilella R, Böhmer F, Ostman A . Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1 . J. Biol. Chem. . 275 . 21 . 16219–26 . 2000 . 10821867 . 10.1074/jbc.275.21.16219 . free .
• del Pozo V, Pirotto F, Cárdaba B, Cortegano I, Gallardo S, Rojo M, Arrieta I, Aceituno E, Palomino P, Gaya A, Lahoz C . Expression on human eosinophils of CD148: a membrane tyrosine phosphatase. Implications in the effector function of eosinophils . J. Leukoc. Biol. . 68 . 1 . 31–7 . 2000 . 10.1189/jlb.68.1.31 . 10914487 . 14259114 . free .
• Baker JE, Majeti R, Tangye SG, Weiss A . Protein Tyrosine Phosphatase CD148-Mediated Inhibition of T-Cell Receptor Signal Transduction Is Associated with Reduced LAT and Phospholipase Cγ1 Phosphorylation . Mol. Cell. Biol. . 21 . 7 . 2393–403 . 2001 . 11259588 . 86872 . 10.1128/MCB.21.7.2393-2403.2001 .
• Persson C, Engström U, Mowbray SL, Ostman A . Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1 . FEBS Lett. . 517 . 1–3 . 27–31 . 2002 . 12062403 . 10.1016/S0014-5793(02)02570-X . 13481032 . free .
• Ruivenkamp CA, van Wezel T, Zanon C, Stassen AP, Vlcek C, Csikós T, Klous AM, Tripodis N, Perrakis A, Boerrigter L, Groot PC, Lindeman J, Mooi WJ, Meijjer GA, Scholten G, Dauwerse H, Paces V, van Zandwijk N, van Ommen GJ, Demant P . Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers . Nat. Genet. . 31 . 3 . 295–300 . 2002 . 12089527 . 10.1038/ng903 . 12338558 .
• Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B . The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn) . Oncogene . 21 . 46 . 7067–76 . 2002 . 12370829 . 10.1038/sj.onc.1205858 . 25745858 .
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Dong HY, Shahsafaei A, Dorfman DM . CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells . Leuk. Lymphoma . 43 . 9 . 1855–8 . 2003 . 12685844 . 10.1080/1042819021000006385 . 37520677 .
• Kellie S, Craggs G, Bird IN, Jones GE . The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation . J. Cell Sci. . 117 . Pt 4 . 609–18 . 2004 . 14709717 . 10.1242/jcs.00879 . 12250178 . free .
• Massa A, Barbieri F, Aiello C, Arena S, Pattarozzi A, Pirani P, Corsaro A, Iuliano R, Fusco A, Zona G, Spaziante R, Florio T, Schettini G . The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation . J. Biol. Chem. . 279 . 28 . 29004–12 . 2004 . 15123617 . 10.1074/jbc.M403573200 . free.

Notes and References

1. Ostman A, Yang Q, Tonks NK . Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density . Proc Natl Acad Sci U S A . 91 . 21 . 9680–4 . Nov 1994 . 7937872 . 44880 . 10.1073/pnas.91.21.9680 . 1994PNAS...91.9680O . free .
2. Honda H, Inazawa J, Nishida J, Yazaki Y, Hirai H . Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta . Blood . 84 . 12 . 4186–94 . Jan 1995 . 7994032 . 10.1182/blood.V84.12.4186.bloodjournal84124186. free .
3. Web site: Entrez Gene: PTPRJ protein tyrosine phosphatase, receptor type, J.
4. Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B . The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn) . Oncogene . 21 . 46 . 7067–76 . Oct 2002 . 12370829 . 10.1038/sj.onc.1205858 . 25745858 .