PTPRCAP explained

Protein tyrosine phosphatase receptor type C-associated protein is an enzyme that in humans is encoded by the PTPRCAP gene.^[1]

The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein.^[1]

Further reading

• Schraven B . LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes . J. Biol. Chem. . 269 . 46 . 29102–11 . 1994 . 7961877 . Schoenhaut D . Bruyns E . Koretzky . G . Eckerskorn . C . Wallich . R . Kirchgessner . H . Sakorafas . P . Labkovsky . B . 10.1016/S0021-9258(19)62018-1 . free .
• Bruyns E . Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45 . J. Biol. Chem. . 270 . 52 . 31372–6 . 1996 . 8537410 . 10.1074/jbc.270.52.31372 . Hendricks-Taylor LR . Meuer S . Koretzky . GA . Schraven . B . free .
• Bruyns E . Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes . Genomics . 38 . 1 . 79–83 . 1997 . 8954783 . 10.1006/geno.1996.0595 . Mincheva A . Bruyns RM . Kirchgessner . Henning . Weitz . Sandra . Lichter . Peter . Meuer . Stefan . Schraven . Burkhart .
• Kung C . CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction . Eur. J. Immunol. . 29 . 12 . 3951–5 . 2000 . 10602003 . 10.1002/(SICI)1521-4141(199912)29:12<3951::AID-IMMU3951>3.0.CO;2-9 . Okumura M . Seavitt JR . Noll . Michelle E. . White . Lynn S. . Pingel . Jeanette T. . Thomas . Matthew L. . 4962507 .
• Woods ML . A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor . EMBO J. . 20 . 6 . 1232–44 . 2001 . 11250890 . 10.1093/emboj/20.6.1232 . 145515 . Kivens WJ . Adelsman MA . Qiu . Yun . August . Avery . Shimizu . Yoji .
• Kirchgessner H . The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain . J. Exp. Med. . 193 . 11 . 1269–84 . 2001 . 11390434 . 10.1084/jem.193.11.1269 . 2193385 . Dietrich J . Scherer J . Isomaki . P. . Korinek . V. . Hilgert . I. . Bruyns . E. . Leo . A. . Cope . A. P. .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Vogel A, Strassburg CP, Manns MP . 77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link . Genes Immun. . 4 . 1 . 79–81 . 2003 . 12595907 . 10.1038/sj.gene.6363918 . 19853676 .
• Cocco E . PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients . J. Neurol. . 251 . 9 . 1085–8 . 2004 . 15372250 . 10.1007/s00415-004-0485-1 . Murru MR . Melis C . Schirru . Lucia . Solla . Elisabetta . Lai . Marina . Rolesu . Marcella . Marrosu . Mariagiovanna . 35718298 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Web site: Entrez Gene: PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein.