PTPN3 explained

Tyrosine-protein phosphatase non-receptor type 3 is an enzyme that in humans is encoded by the PTPN3 gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta.

Interactions

PTPN3 has been shown to interact with YWHAB.^[3]

Further reading

• Arimura Y, Hinoda Y, Itoh F, Takekawa M, Tsujisaki M, Adachi M, Imai K, Yachi A . cDNA cloning of new protein tyrosine phosphatases in the human colon. . Tumour Biol. . 13 . 3 . 180–6 . 1992 . 1626183 . 10.1159/000217763 .
• Ikuta S, Itoh F, Hinoda Y, Toyota M, Makiguchi Y, Imai K, Yachi A . Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. . J. Gastroenterol. . 29 . 6 . 727–32 . 1995 . 7874267 . 10.1007/BF02349278 . 31617297 .
• Itoh F, Ikuta S, Hinoda Y, Arimura Y, Ohe M, Adachi M, Ariyama T, Inazawa J, Imai K, Yachi A . Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins. . Int. J. Cancer . 55 . 6 . 947–51 . 1994 . 8253532 . 10.1002/ijc.2910550612 . 32380202 .
• Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK . Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein. . J. Biol. Chem. . 272 . 43 . 27281–7 . 1997 . 9341175 . 10.1074/jbc.272.43.27281 . free .
• Zhang SH, Liu J, Kobayashi R, Tonks NK . Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1. . J. Biol. Chem. . 274 . 25 . 17806–12 . 1999 . 10364224 . 10.1074/jbc.274.25.17806 . free .
• Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T . Subcellular localization of intracellular protein tyrosine phosphatases in T cells. . Eur. J. Immunol. . 30 . 8 . 2412–21 . 2000 . 10940933 . 10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J . 8132613 .
• Zheng Y, Schlondorff J, Blobel CP . Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. . J. Biol. Chem. . 277 . 45 . 42463–70 . 2003 . 12207026 . 10.1074/jbc.M207459200 . free .
• Sozio MS, Mathis MA, Young JA, Wälchli S, Pitcher LA, Wrage PC, Bartók B, Campbell A, Watts JD, Aebersold R, Hooft van Huijsduijnen R, van Oers NS . PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit. . J. Biol. Chem. . 279 . 9 . 7760–9 . 2004 . 14672952 . 10.1074/jbc.M309994200 . free .
• Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML . Substrate-trapping techniques in the identification of cellular PTP targets. . Methods . 35 . 1 . 44–53 . 2005 . 15588985 . 10.1016/j.ymeth.2004.07.007 .
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Jespersen T, Gavillet B, van Bemmelen MX, Cordonier S, Thomas MA, Staub O, Abriel H . Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1. . Biochem. Biophys. Res. Commun. . 348 . 4 . 1455–62 . 2006 . 16930557 . 10.1016/j.bbrc.2006.08.014 .
• Jing M, Bohl J, Brimer N, Kinter M, Vande Pol SB . Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins. . J. Virol. . 81 . 5 . 2231–9 . 2007 . 17166906 . 1865939 . 10.1128/JVI.01979-06 .
• Töpffer S, Müller-Schiffmann A, Matentzoglu K, Scheffner M, Steger G . Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. . J. Gen. Virol. . 88 . Pt 11 . 2956–65 . 2007 . 17947517 . 10.1099/vir.0.83123-0 . free .

Notes and References

1. Yang Q, Tonks NK . Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin . Proc Natl Acad Sci USA . 88 . 14 . 5949–53 . August 1991 . 1648725 . 51999 . 10.1073/pnas.88.14.5949 . 1991PNAS...88.5949Y . free .
2. Web site: Entrez Gene: PTPN3 protein tyrosine phosphatase, non-receptor type 3.
3. Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK . Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein . J. Biol. Chem. . 272 . 43 . 27281–7 . October 1997 . 9341175 . 10.1074/jbc.272.43.27281 . free .