PTPN18 explained

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.^{[1] [2]}

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The biological function of this PTP has not yet been determined.

Interactions

PTPN18 has been shown to interact with PSTPIP1.^[3]

Further reading

• Spencer S, Dowbenko D, Cheng J, etal . PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow–associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase . J. Cell Biol. . 138 . 4 . 845–60 . 1997 . 9265651 . 10.1083/jcb.138.4.845 . 2138048 .
• Dowbenko D, Spencer S, Quan C, Lasky LA . Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein . J. Biol. Chem. . 273 . 2 . 989–96 . 1998 . 9422760 . 10.1074/jbc.273.2.989 . free .
• Wu Y, Dowbenko D, Lasky LA . PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase . J. Biol. Chem. . 273 . 46 . 30487–96 . 1998 . 9804817 . 10.1074/jbc.273.46.30487 . free .
• Wang B, Lemay S, Tsai S, Veillette A . SH2 Domain-Mediated Interaction of Inhibitory Protein Tyrosine Kinase Csk with Protein Tyrosine Phosphatase-HSCF . Mol. Cell. Biol. . 21 . 4 . 1077–88 . 2001 . 11158295 . 10.1128/MCB.21.4.1077-1088.2001 . 99562 .
• Cong F, Spencer S, Côté JF, etal . Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation . Mol. Cell . 6 . 6 . 1413–23 . 2001 . 11163214 . 10.1016/S1097-2765(00)00138-6 . free .
• Wise CA, Gillum JD, Seidman CE, etal . Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder . Hum. Mol. Genet. . 11 . 8 . 961–9 . 2003 . 11971877 . 10.1093/hmg/11.8.961 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Shiota M, Tanihiro T, Nakagawa Y, etal . Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone . Mol. Endocrinol. . 17 . 4 . 534–49 . 2004 . 12554790 . 10.1210/me.2002-0187 . free .
• Gensler M, Buschbeck M, Ullrich A . Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1 . J. Biol. Chem. . 279 . 13 . 12110–6 . 2004 . 14660651 . 10.1074/jbc.M309527200 . free .
• Blanchetot C, Chagnon M, Dubé N, etal . Substrate-trapping techniques in the identification of cellular PTP targets . Methods . 35 . 1 . 44–53 . 2005 . 15588985 . 10.1016/j.ymeth.2004.07.007 .
• Zhang Y, Wolf-Yadlin A, Ross PL, etal . Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules . Mol. Cell. Proteomics . 4 . 9 . 1240–50 . 2005 . 15951569 . 10.1074/mcp.M500089-MCP200 . free .
• Tao WA, Wollscheid B, O'Brien R, etal . Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry . Nat. Methods . 2 . 8 . 591–8 . 2005 . 16094384 . 10.1038/nmeth776 . 20475874 .
• Gandhi TK, Chandran S, Peri S, etal . A bioinformatics analysis of protein tyrosine phosphatases in humans . DNA Res. . 12 . 2 . 79–89 . 2007 . 16303740 . 10.1093/dnares/12.2.79 . free .

Notes and References

1. Kim YW, Wang H, Sures I, Lammers R, Martell KJ, Ullrich A . Characterization of the PEST family protein tyrosine phosphatase BDP1 . Oncogene . 13 . 10 . 2275–9 . January 1997 . 8950995 .
2. Web site: Entrez Gene: PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived).
3. Spencer . S . Dowbenko D . Cheng J . Li W . Brush J . Utzig S . Simanis V . Lasky L A . August 1997 . PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow–associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase . J. Cell Biol. . 138 . 4 . 845–60 . UNITED STATES. 0021-9525. 9265651 . 10.1083/jcb.138.4.845 . 2138048 .