PTPRO explained

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.^{[1] [2] [3]}

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.

Further reading

• Seimiya H, Sawabe T, Inazawa J, Tsuruo T . Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents . Oncogene . 10 . 9 . 1731–8 . 1995 . 7753550 .
• Feito MJ . gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules . Int. Immunol. . 9 . 8 . 1141–7 . 1997 . 9263011 . 10.1093/intimm/9.8.1141 . Bragardo M . Buonfiglio D . Bonissoni . S . Bottarel . F . Malavasi . F . Dianzani . U . free .
• Avraham S . Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells . Gene . 204 . 1–2 . 5–16 . 1998 . 9434160 . 10.1016/S0378-1119(97)00420-4 . London R . Tulloch GA . Ellis . Martin . Fu . Yigong . Jiang . Shuxian . White . Robert A . Painter . Christopher . Steinberger . A.A .
• Taniguchi Y . The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor . Blood . 94 . 2 . 539–49 . 1999 . 10397721 . 10.1182/blood.V94.2.539. London R . Schinkmann K . Jiang . S . Avraham . H .
• Aguiar RC . PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest . Blood . 94 . 7 . 2403–13 . 1999 . 10498613 . 10.1182/blood.V94.7.2403.419k39_2403_2413. Yakushijin Y . Kharbanda S . Tiwari . S . Freeman . GJ . Shipp . MA . 15259010 .
• Wang Z . Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells . Arch. Biochem. Biophys. . 390 . 1 . 9–18 . 2001 . 11368509 . 10.1006/abbi.2001.2370 . Bhattacharya N . Meyer MK . Seimiya . H . Tsuruo . T . Tonani . JA . Magnuson . NS .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Chen L . Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation . Blood . 108 . 10 . 3428–33 . 2007 . 16888096 . 10.1182/blood-2006-03-013821 . Juszczynski P . Takeyama K . Aguiar . R. C. T. . Shipp . M. A. . free .
• Motiwala T . Methylation and Silencing of Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia . Clin. Cancer Res. . 13 . 11 . 3174–81 . 2007 . 17545520 . 10.1158/1078-0432.CCR-06-1720 . Majumder S . Kutay H . Smith . D. S. . Neuberg . D. S. . Lucas . D. M. . Byrd . J. C. . Grever . M. . Jacob . S. T. . 3074612 .
• Tian J . Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy . J. Int. Med. Res. . 35 . 3 . 338–45 . 2007 . 17593862 . 10.1177/147323000703500308. Wang HP . Mao YY . Jin . J . Chen . JH . 24500200 .

Notes and References

1. Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC . GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit . J Biol Chem . 269 . 31 . 19953–62 . Sep 1994 . 10.1016/S0021-9258(17)32113-0 . 7519601 . free .
2. Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE . Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13 . Genomics . 27 . 1 . 174–81 . Oct 1995 . 7665166 . 10.1006/geno.1995.1021 .
3. Web site: Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O.