PTGFRN explained

Prostaglandin F2 receptor negative regulator is a protein that in humans is encoded by the PTGFRN gene.^{[1] [2]} PTGFRN has also been designated as CD315 (cluster of differentiation 315).

Interactions

PTGFRN has been shown to interact with CD9^{[3] [4]} and CD81.^{[3] [4]}

Further reading

• Orlicky DJ . Negative regulatory activity of a prostaglandin F2 alpha receptor associated protein (FPRP). . Prostaglandins Leukot. Essent. Fatty Acids . 54 . 4 . 247–59 . 1997 . 8804121 . 10.1016/S0952-3278(96)90055-1 .
• Orlicky DJ, Lieber JG, Morin CL, Evans RM . Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells. . J. Lipid Res. . 39 . 6 . 1152–61 . 1998 . 10.1016/S0022-2275(20)32539-6 . 9643346 . free .
• Nagase T, Kikuno R, Ishikawa KI, etal . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 7 . 1 . 65–73 . 2000 . 10718198 . 10.1093/dnares/7.1.65 . free .
• Stipp CS, Orlicky D, Hemler ME . FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein. . J. Biol. Chem. . 276 . 7 . 4853–62 . 2001 . 11087758 . 10.1074/jbc.M009859200 . free .
• Charrin S, Le Naour F, Oualid M, etal . The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. . J. Biol. Chem. . 276 . 17 . 14329–37 . 2001 . 11278880 . 10.1074/jbc.M011297200 . free .
• Clark KL, Zeng Z, Langford AL, etal . PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins. . J. Immunol. . 167 . 9 . 5115–21 . 2001 . 11673522 . 10.4049/jimmunol.167.9.5115. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Yang XH, Kovalenko OV, Kolesnikova TV, etal . Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization. . J. Biol. Chem. . 281 . 18 . 12976–85 . 2006 . 16537545 . 10.1074/jbc.M510617200 . free .
• Sala-Valdés M, Ursa A, Charrin S, etal . EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. . J. Biol. Chem. . 281 . 28 . 19665–75 . 2006 . 16690612 . 10.1074/jbc.M602116200 . free .

Notes and References

1. Orlicky DJ, Berry R, Sikela JM . Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein . Hum Genet . 97 . 5 . 655–8 . Jul 1996 . 8655148 . 10.1007/BF02281878 . 21645802 .
2. Web site: Entrez Gene: PTGFRN prostaglandin F2 receptor negative regulator.
3. Charrin . S . Le Naour F . Oualid M . Billard M . Faure G . Hanash S M . Boucheix C . Rubinstein E . Apr 2001 . The major CD9 and CD81 molecular partner. Identification and characterization of the complexes . J. Biol. Chem. . 276 . 17 . 14329–37 . United States. 0021-9258. 11278880 . 10.1074/jbc.M011297200 . free .
4. Stipp . C S . Orlicky D . Hemler M E . Feb 2001 . FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein . J. Biol. Chem. . 276 . 7 . 4853–62 . United States. 0021-9258. 11087758 . 10.1074/jbc.M009859200 . free .