O-phosphoseryl-tRNASec kinase explained

O-phosphoseryl-tRNASec kinase
Ec Number:	2.7.1.164
Cas Number:	91273-83-5

O-phosphoseryl-tRNASec kinase (PSTK, phosphoseryl-tRNA[Ser]Sec kinase, phosphoseryl-tRNASec kinase) is an enzyme with systematic name ATP:L-seryl-tRNASec O-phosphotransferase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

ATP + L-seryl-tRNASec

\rightleftharpoons ADP + O-phospho-L-seryl-tRNASec

In archaea and eukarya selenocysteine formation is achieved by a two-step process.

Notes and References

1. Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL . Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase . Proceedings of the National Academy of Sciences of the United States of America . 101 . 35 . 12848–53 . August 2004 . 15317934 . 516484 . 10.1073/pnas.0402636101 . free .
2. Sherrer RL, O'Donoghue P, Söll D . Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation . Nucleic Acids Research . 36 . 4 . 1247–59 . March 2008 . 18174226 . 2275090 . 10.1093/nar/gkm1134 .
3. Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC . Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer . Biochemistry . 37 . 10 . 3518–28 . March 1998 . 9521673 . 10.1021/bi972177k .