PSRC1 explained

Proline/serine-rich coiled-coil protein 1 is a protein that in humans is encoded by the PSRC1 gene.^{[1] [2] [3]}

This gene encodes a proline-rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. Alternatively spliced transcript variants encoding different isoforms have been described.

Further reading

• Kathiresan S, Melander O, Guiducci C, etal . Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans . Nat. Genet. . 40 . 2 . 189–97 . 2008 . 18193044 . 10.1038/ng.75 . 2682493 .
• Wallace C, Newhouse SJ, Braund P, etal . Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia . Am. J. Hum. Genet. . 82 . 1 . 139–49 . 2008 . 18179892 . 10.1016/j.ajhg.2007.11.001 . 2253977 .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Wan D, Gong Y, Qin W, etal . Large-scale cDNA transfection screening for genes related to cancer development and progression . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 10.1073/pnas.0404089101 . 524842 . 2004PNAS..10115724W . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Lo PK, Wang FF . Cloning and characterization of human and mouse DDA3 genes . Biochim Biophys Acta . 1579 . 2–3 . 214–8 . Nov 2002 . 12427559 . 10.1016/s0167-4781(02)00512-2.
2. Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, Tang PP, Wang FF . Identification of a novel mouse p53 target gene DDA3 . Oncogene . 18 . 54 . 7765–74 . Feb 2000 . 10618717 . 10.1038/sj.onc.1203167 . free .
3. Web site: Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1.