PSB-SB-1202 explained

PSB-SB-1202 is a coumarin derivative which is an agonist at the cannabinoid receptors CB₁ and CB₂, with a CB₁ Ki of 32nM and a CB₂ Ki of 49nM.^[1] It is also a weak antagonist at the related receptor GPR55, with an IC₅₀ of 6350nM, but has no significant affinity for GPR18.^[2]

See also

• PSB-SB-487

Notes and References

1. Rempel V, Volz N, Hinz S, Karcz T, Meliciani I, Nieger M, Wenzel W, Bräse S, Müller CE . 6 . 7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists . Journal of Medicinal Chemistry . 55 . 18 . 7967–77 . September 2012 . 22916707 . 10.1021/jm3008213 .
2. Rempel V, Volz N, Gläser F, Nieger M, Bräse S, Müller CE . Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold . Journal of Medicinal Chemistry . 56 . 11 . 4798–810 . June 2013 . 23679955 . 10.1021/jm4005175 .