PRSS3 explained

Protease, serine, 3 is a protein that in humans is encoded by the PRSS3 gene.^[1]

Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.

Further reading

• Koistinen H, Koistinen R, Zhang WM, Valmu L, Stenman UH . Nexin-1 inhibits the activity of human brain trypsin . Neuroscience . 160 . 1 . 97–102 . April 2009 . 19249338 . 10.1016/j.neuroscience.2009.02.042 . 23924027 .
• Tani T, Kawashima I, Mita K, Takiguchi Y . Nucleotide sequence of the human pancreatic trypsinogen III cDNA . Nucleic Acids Research . 18 . 6 . 1631 . March 1990 . 2326201 . 330537 . 10.1093/nar/18.6.1631 .
• Hayashi H, Kohno T, Yasui K, Murota H, Kimura T, Duncan GS, Nakashima T, Yamamoto K, Katayama I, Ma Y, Chua KJ, Suematsu T, Shimokawa I, Akira S, Kubo Y, Mak TW, Matsuyama T . Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription . Proceedings of the National Academy of Sciences of the United States of America . 108 . 46 . 18766–71 . November 2011 . 22042864 . 3219097 . 10.1073/pnas.1116273108 . 2011PNAS..10818766H . free .
• Salameh MA, Robinson JL, Navaneetham D, Sinha D, Madden BJ, Walsh PN, Radisky ES . The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin . The Journal of Biological Chemistry . 285 . 3 . 1939–49 . January 2010 . 19920152 . 2804352 . 10.1074/jbc.M109.057216 . free .
• Masson E, Le Maréchal C, Chen JM, Férec C . Absence of mesotrypsinogen gene (PRSS3) copy number variations in patients with chronic pancreatitis . Pancreas . 37 . 2 . 227–8 . August 2008 . 18665091 . 10.1097/MPA.0b013e3181654b6a .
• Nyaruhucha CN, Kito M, Fukuoka SI . Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance . The Journal of Biological Chemistry . 272 . 16 . 10573–8 . April 1997 . 9099703 . 10.1074/jbc.272.16.10573 . free .
• Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skåregärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW . Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia . The Journal of Biological Chemistry . 282 . 36 . 26089–100 . September 2007 . 17623652 . 10.1074/jbc.M703840200 . free .
• Huntington JA, Read RJ, Carrell RW . Structure of a serpin-protease complex shows inhibition by deformation . Nature . 407 . 6806 . 923–6 . October 2000 . 11057674 . 10.1038/35038119 . 2000Natur.407..923H . 205009937 .

Notes and References

1. Web site: Entrez Gene: Protease, serine, 3 .