PRSS22 explained

Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene.^{[1] [2] [3]}

This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16.^[1]

See also

• tryptase

Further reading

• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697.
• Martin J, Han C, Gordon LA, etal . The sequence and analysis of duplication-rich human chromosome 16. . Nature . 432 . 7020 . 988–94 . 2004 . 15616553 . 10.1038/nature03187 . 2004Natur.432..988M . free .
• Mitsui S, Okui A, Kominami K, etal . A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells. . FEBS J. . 272 . 19 . 4911–23 . 2005 . 16176265 . 10.1111/j.1742-4658.2005.04901.x . 25290079 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.

Notes and References

1. Web site: Entrez Gene: protease.
2. Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL . Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells . J. Biol. Chem. . 276 . 52 . 49169–82 . December 2001 . 11602603 . 10.1074/jbc.M108677200 . free .
3. Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL . Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22 . Blood . 105 . 10 . 3893–901 . May 2005 . 15701722 . 1895090 . 10.1182/blood-2003-10-3501 .