PRSS2 explained

Protease, serine, 2 (trypsin 2) is a protein that in humans is encoded by the PRSS2 gene.^[1]

Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].

Further reading

• Williams SJ, Gotley DC, Antalis TM . Human trypsinogen in colorectal cancer . International Journal of Cancer . 93 . 1 . 67–73 . July 2001 . 11391623 . 10.1002/ijc.1304 . 22649653 . free .
• Mayumi T, Inui K, Maetani I, Yokoe M, Sakamoto T, Yoshida M, Ko S, Hirata K, Takada T . Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis . Pancreas . 41 . 6 . 869–75 . August 2012 . 22481290 . 10.1097/MPA.0b013e3182480ab7 . Urinary Trypsinogen-2 Dipstick for Acute Pancreatitis Study Group of Japanese Society of Abdominal Emergency Medicine (UtrAP Study Group) . 24109182 .
• PRSS1-Related Hereditary Pancreatitis . 1993 . 22379635 . Shelton . C. . Solomon . S. . Larusch . J. . Whitcomb . D. C. . Adam . M. P. . Ardinger . H. H. . Pagon . R. A. . Wallace . S. E. . Bean LJH . Stephens . K. . Amemiya . A. .
• Ahmed M, Forsberg J, Bergsten P . Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry . Journal of Proteome Research . 4 . 3 . 931–40 . 2005 . 15952740 . 10.1021/pr050024a .
• Vilen ST, Suojanen J, Salas F, Risteli J, Ylipalosaari M, Itkonen O, Koistinen H, Baumann M, Stenman UH, Sorsa T, Salo T, Nyberg P . Trypsin-2 enhances carcinoma invasion by processing tight junctions and activating ProMT1-MMP . Cancer Investigation . 30 . 8 . 583–92 . October 2012 . 22909050 . 10.3109/07357907.2012.716467 . 29172202 .
• Lempinen M, Isoniemi H, Mäkisalo H, Nordin A, Halme L, Arola J, Höckerstedt K, Stenman UH . Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures . Journal of Hepatology . 47 . 5 . 677–83 . November 2007 . 17640760 . 10.1016/j.jhep.2007.05.017 .
• Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A . Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes . Journal of Neurovirology . 9 . 3 . 358–71 . June 2003 . 12775419 . 10.1080/13550280390201119 . 22016092 .
• Baptista AM, Jonson PH, Hough E, Petersen SB . The origin of trypsin: evidence for multiple gene duplications in trypsins . Journal of Molecular Evolution . 47 . 3 . 353–62 . September 1998 . 9732462 . 10.1007/PL00006393 . 1998JMolE..47..353B . 15271694 .
• Gao J, Zhu F, Lv S, Li Z, Ling Z, Gong Y, Jie C, Ma L . Identification of pancreatic juice proteins as biomarkers of pancreatic cancer . Oncology Reports . 23 . 6 . 1683–92 . June 2010 . 20428826 . 10.3892/or_00000812 . free .

Notes and References

1. Web site: Entrez Gene: Protease, serine, 2 (trypsin 2) .