PRRX2 explained

Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene.^{[1] [2]}

Function

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.

Further reading

• Tokutomi Y, Araki N, Kataoka K, etal . Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis. . Biochem. Biophys. Res. Commun. . 364 . 4 . 822–30 . 2007 . 17964282 . 10.1016/j.bbrc.2007.10.095 .
• Wissmüller S, Kosian T, Wolf M, etal . The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. . Nucleic Acids Res. . 34 . 6 . 1735–44 . 2006 . 16582099 . 10.1093/nar/gkl105 . 1421504 .
• Gervais C, Mauvieux L, Perrusson N, etal . A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. . Leukemia . 19 . 1 . 145–8 . 2005 . 15496970 . 10.1038/sj.leu.2403565 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Scott KK, Norris RA, Potter SS, etal . GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein. . DNA Cell Biol. . 22 . 2 . 95–105 . 2003 . 12713735 . 10.1089/104454903321515904 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Jones FS, McKean DM, Meech R, etal . Regulation of vascular smooth muscle cell growth and adhesion by paired-related homeobox genes. . Chest . 121 . 3 Suppl . 89S–90S . 2002 . 11893718 . 10.1378/chest.121.3_suppl.89S-a .
• Stelnicki EJ, Arbeit J, Cass DL, etal . Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. . J. Invest. Dermatol. . 111 . 1 . 57–63 . 1998 . 9665387 . 10.1046/j.1523-1747.1998.00238.x . free .

Notes and References

1. Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ . Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome . Mamm Genome . 11 . 11 . 1000–5 . Mar 2001 . 11063257 . 10.1007/s003350010193 . 9937434 .
2. Web site: Entrez Gene: PRRX2 paired related homeobox 2.