Proline-rich protein 23C is a protein that in humans is encoded by the proline-rich 23C (PRR23C) gene.
PRR23C Homo sapiens is located on the long arm of chromosome 3, (3q23) on the antisense strand.[1] When pertaining to the mRNA of PRR23C Homo sapiens, it is 2,791 bp in length.[2] PRR23C Homo sapiens has one exon covering the entire length of mRNA (1-2,791 bp).[3] PRR23C Homo sapiens has a clone name of FLJ46210.[4]
PRR23C Homo sapiens is expressed in the testis.[5] Ottolini et al. (2014) discussed the PRR23 family to which they revealed that through RNA sequencing data, that PRR23A, PRR23B and PRR23C are testis-specific genes.[6] Ottolini et al. (2014) believes that this family may be a crucial part for the male reproductive system given their RNA-seq data findings.[7]
Proline-rich protein 23C Homo sapiens is 262 amino acids long[8] with a calculated molecular weight of 27,674 Da.[9] Proline-rich protein 23C Homo sapiens has a domain of unknown function (DUF2476) that spans the majority of the protein (1-259 aa) which is a conserved domain.[10] DUF2476 belongs to pfam10630 which is a part of superfamily c|11241.[11] DUF2476 is a family of proteins that are rich in proline residues and have unknown function.[12] Proline-rich protein 23C is the preferred name but other aliases include proline-rich protein 23A.[13]
Proline is predicted to be the most abundant amino acid in proline-rich protein 23C Homo sapiens.[14] In comparison to the prevalence of amino acids in other human proteins, it is predicted that proline-rich protein 23C Homo sapiens has a higher abundance of proline along with very low abundances of asparagine, threonine, and lysine.[15] Orthologs for this protein are predicted to also have a high abundance of proline.[16]
The basal isoelectric point for PRR23C Homo sapiens was 4.48 (pH) according to phoshosite.org.[17]
Proline-rich protein 23C is predicted to localize to the nucleus for the human protein and its orthologs.[18] There are predicted nuclear localization signals seen in both the human proline-rich protein 23C and its orthologs.[19]
PRR23C Homo sapiens is strictly conserved in mammals.[20] The table below lists mammalian orthologs for PRR23C Homo sapiens .[21]
| Genus & Species | Common Name | Accession Number[22] | Seq. Length[23] | Seq. Identity[24] | Seq. Similarity[25] |
|---|---|---|---|---|---|
| Homo sapiens | NP_001128129.1 | 262 aa | 100% | 100% | |
| Pan troglodytes | XP_003310067.1 | 263 aa | 98.50% | 98% | |
| Gorilla gorilla gorilla | XP_004037787.1 | 263 aa | 96.60% | 98% | |
| Pongo pygmaeus | XP_002814147.1 | 263 aa | 94.70% | 95% | |
| Nomascus leucogenys | XP_003265349.1 | 262 aa | 94.70% | 95% | |
| Chlorocebus sabaeus | XP_008007123.1 | 263 aa | 92% | 94% | |
| Rhinopithecus roxellana | XP_010365056.1 | 263 aa | 91.60% | 93% | |
| Papio anubis | XP_003895087.1 | 263 aa | 94.70% | 93% | |
| Callithrix jacchus | XP_002759594.1 | 248 aa | 72.90% | 77% | |
| Otolemur garnettii | XP_003789481.1 | 267 aa | 66.50% | 71% | |
| Ceratotherium simum simum | XP_004419371.1 | 263 aa | 63.70% | 75% | |
| Pteropus alecto | XP_006907344.1 | 268 aa | 50.90% | 68% | |
| Myotis lucifugus | XP_006083994.1 | 257 aa | 61.20% | 64% | |
| Bubalus bubalis | XP_006070045.1 | 258 aa | 55.40% | 62% | |
| Bison bison bison | XP_010856601.1 | 258 aa | 51.90% | 61% | |
| Bos mutus | XP_005909007.1 | 258 aa | 51.50% | 61% | |
| Lipotes vexillifer | XP_007458979.1 | 260 aa | 51.50% | 64% | |
| Tursiops truncatus | XP_004330081.1 | 261 aa | 54.50% | 61% | |
| Balaenoptera acutorostrata scammoni | XP_007170446.1 | 255 aa | 53.60% | 61% | |
| Physeter catodon | XP_007117538.1 | 260 aa | 53.80% | 64% | |
| Peromyscus maniculatus bairdii | XP_006975251.1 | 266 aa | 50.90% | 60% | |
There were two paralogs found for PRR23C Homo sapiens: PRR23B and PRR23A. Both have similar sequence identities with PRR23B having 86% identity and PRR23A having 85% identity.[26]